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Date Published: 18/09/2023
Abstract Views: 206
Views pdf: 170
DOI: https://doi.org/10.51298/vmj.v530i1.6585
Issue
Vol. 530 No. 1 (2023)
Section
Các bài báo
How to Cite
Vũ, T. H. H. (2023). INVESTIGATION OF THE TOXICITY OF BERBERIN CLORID USING ZEBRAFISH MODEL (DANIO RERIO). Vietnam Medical Journal, 530(1). https://doi.org/10.51298/vmj.v530i1.6585

INVESTIGATION OF THE TOXICITY OF BERBERIN CLORID USING ZEBRAFISH MODEL (DANIO RERIO)

Thị Hồng Hạnh Vũ1,
1 Hanoi University of Pharmacy

Main Article Content

Abstract

Berberin – natural alkaloid compounds - have been widely used to treat gastrointestinal diseases such as abdominal pain, diarrhea. Nowadays, several modern pharmacological properties of berberin have been investigated against some pathologicial conditions such as diabetes, heart failure, cancer and neurodegenerative disorders. Thus, the investigation of animal model to examine the pharmacological properties of berberin has been necessary. In this research, the toxicity of berberin (from 1 to 100 µg/mL) was explored using the zebrafish model (from 1hpf to 120 hpf). The result showed that berberin (70 µg/mL) were toxic to zebrafish by reducing the development of zebrafish, reducing the heart beat and reducing the survival rate of zebrafish. The lethal death 50 of berberin was 90.40 µg/mL.

Article Details

Keywords

Zebrafish, berberin, toxicixity

References

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