SOLID ORGAN AND HEMATOPOIETIC STEM CELL TRANSPLANTATION AT CHILDREN'S HOSPITAL 2: CHALLENGES AN ACHIEVEMENTS

Thanh Trí Trần1,, Phi Duy Hồ1, Hồng Vân Khánh Nguyễn1, Thị Vũ Quỳnh Huỳnh1, Đình Văn Nguyễn1, Tấn Đức Phan1, Xuân Vinh Đặng1, Ngọc Thạch Phạm1, Hữu Tùng Trịnh1, Đông A Trần1
1 Children's Hospital 2 - City. Ho Chi Minh

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Abstract

Background: The need for liver, kidney, and stem cell transplants in children increases. Children's Hospital 2 (ND2) develops these techniques as a last-line referral pediatric hospital and the only public pediatric organ transplant center in the South of Vietnam. Patients and methods: Children who received liver, kidney, and hematopoietic stem cell transplants in ND2 were retrospectively reviewed. Results: There were 25 cases of living-related donor liver transplantation from 2005 to 2022. Follow-up time was 4 months - 17 years. The survival rate of liver recipients was 20/25 cases (80%), no complication in liver living donors was observed. There were 24 cases of kidney transplantation from 2004 to 2022 (22 living donors and 2 brain-dead donors). Follow-up time was 1-16 years. Well-functioning kidney rate was 18/24 cases (75%). Survival rate was 21/24 cases (87.5%). There were 5 cases of hematopoietic stem cell transplantation from 2020 to 2023. Follow-up time was 2-32 months. Survival rate was 4/5 cases (80%). Conclusion: Organ transplantation at ND2 was well-developed with support from experienced domestic and international centers. Existing obstacles including the lack of financial support, personnel shortages, and inadequacy in equipment, facilities and immunosuppressive drugs for organ transplants need to be addressed. As for liver and kidney transplants, it is necessary to increase the organ pool for children from brain-dead donors.

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References

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