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THE PREDICTIVE VALUE OF SERUM NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN FOR ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE PANCREATITIS
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Abstract
Objectives: Determine the predictive value of serum NGAL concentration upon admission for acute kidney injury (AKI) in patients with acute pancreatitis. Methods: A prospective cohort study followed 239 patients diagnosed with acute pancreatitis according to the Atlanta 2012 criteria. NGAL testing and biochemical analysis at the time of hospital admission and at various other time points during the treatment process. Results: The average age of the study population was 46.07 ± 13.17 years, with a male-to-female ratio of 76.2%. 8.36% of acute pancreatitis patients had acute kidney injury. Upon admission, the median serum NGAL concentration in patients with acute pancreatitis and acute kidney injury was 529.8 (476.4-639.4) ng/ml, which was higher than the group without acute kidney injury, which was 429.8 (253.5-545.9) ng/ml, p>0.05. There was a weak correlation between serum NGAL concentration upon admission and the severity of acute pancreatitis, renal function tests, and pancreatic enzymes. Serum NGAL concentration at the time of admission shows a fairly good predictive ability for acute kidney injury in patients with acute pancreatitis (AUC=0.73) with a cutoff value of 446.97 ng/mL, sensitivity of 83.3%, and specificity of 56.4%. Conclusion: The incidence rate of acute kidney injury is 8.36%. The median serum NGAL concentration in patients with acute pancreatitis and acute kidney injury at admission was 529.8 (476.4-639.4) ng/mL. The serum NGAL concentration upon admission shows a fairly good prognostic ability for acute kidney injury in patients with acute pancreatitis (AUC=0.73) with a cutoff value of 446.97 ng/mL, sensitivity of 83.3%, and specificity of 56.4%.
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Keywords
Acute kidney injury (AKI), KDIGO, acute pancreatitis, Serum Neutrophil Gelatinase Associated Lipocalin.
References
2. E. Singer, L. Markó, N. Paragas, et al. (2013). Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications. Acta Physiol (Oxf), 207(4): 663-72.
3. Lê Thị Diễm Tuyết (2010). Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và điều trị suy thận cấp tại khoa điều trị tích cực bệnh viện Bạch Mai. Luận án tiến sĩ y học, Trường Đại Học Y Hà Nội.
4. H. Li, Z. Qian, Z. Liu, et al. (2010). Risk factors and outcome of acute renal failure in patients with severe acute pancreatitis. J Crit Care, 25(2): 225-9.
5. M. Sporek, A. Gala-Błądzińska, P. Dumnicka, et al. (2016). Urine NGAL is useful in the clinical evaluation of renal function in the early course of acute pancreatitis. Folia Med Cracov, 56(1): 13-25.
6. Phan Thị Xuân (2018). Giá trị của Neutrophil Gelatinase Associated Lipocaline huyết tương trong chẩn đoán sớm tổn thương thận cấp và tiên lượng ở bệnh nhân điều trị tích cực. Luận án tiến sĩ y học, Đại học Y dược Thành Phố Hồ Chí Minh.
7. P. K. Siddappa, R. Kochhar, P. Sarotra, et al. (2019). Neutrophil gelatinase-associated lipocalin: An early biomarker for predicting acute kidney injury and severity in patients with acute pancreatitis. JGH Open, 3(2): 105-110.
8. M. Haase, R. Bellomo, P. Devarajan, et al. (2009).Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis, 54(6): 1012-24.