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Date Published: 18/09/2023
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DOI: https://doi.org/10.51298/vmj.v530i1.6637
Issue
Vol. 530 No. 1 (2023)
Section
Các bài báo
How to Cite
Hoàng, T. N. V., Trần, T. N. V., & Bùi, T. T. Q. (2023). EFFICACY, EFFECTIVENESS, AND SAFETY OF DAPAGLIFLOZIN IN CHRONIC KIDNEY DISEASE MANAGEMENT: A SYSTEMATIC REVIEW. Vietnam Medical Journal, 530(1). https://doi.org/10.51298/vmj.v530i1.6637

EFFICACY, EFFECTIVENESS, AND SAFETY OF DAPAGLIFLOZIN IN CHRONIC KIDNEY DISEASE MANAGEMENT: A SYSTEMATIC REVIEW

Thy Nhạc Vũ Hoàng1,, Thị Ngọc Vân Trần1, Thị Thu Quỳnh Bùi2
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 AstraZeneca Vietnam

Main Article Content

Abstract

Objectives: This systematic review aimed to evaluate the efficacy, effectiveness, and safety of dapagliflozin in the management of chronic kidney disease (CKD). Methods: A comprehensive search strategy was employed to identify relevant studies published on PubMed, Embase, and Cochrane as of December 21, 2022. The efficacy and effectiveness outcomes evaluated were composite cardiorenal outcomes, renal outcomes, cardiovascular outcomes, and all-cause mortality. Safety was assessed by comparing the frequency of adverse events. Results: The review identified 8 studies that demonstrated the efficacy and effectiveness of dapagliflozin in improving cardiorenal outcomes, renal outcomes, cardiovascular outcomes, and all-cause mortality in CKD patients at different stages, with or without diabetes type 2, heart failure, or atherosclerotic cardiovascular disease. The frequency of adverse events was comparable between groups, and there were no statistically significant differences between geographic regions (p>0.05). Conclusion: The results suggest that dapagliflozin is a safe and effective treatment option for the management of CKD, improving renal and cardiovascular outcomes and reducing mortality.

Article Details

Keywords

dapagliflozin, chronic kidney disease, efficacy, effectiveness, safety, systematic review.

References

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