ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG BỆNH VIÊM NÃO TỦY RẢI RÁC CÓ KHÁNG THỂ KHÁNG MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG) Ở TRẺ EM

Abstract

Objectives: Describe clinical and subclinical of pediatric Acute Disseminating Encephalomyelitis (ADEM) with antibodies to myelin oligodendrocyte glycoprotein. Method: To report clinical and subclinical characteristics of 22 patients diagnosed Acute disseminating encephalomyelitis (ADEM) with antibodies to Myelin oligodendrocyte glycoprotein (MOG) from November 2021 to January 2023. All of patients were positive for MOG-IgG. Results: The median age at disease onset was 71,5 months ([IQR] from 51,75 to 113), the median diagnosed time was 7 days. The most common symptoms were altered consciousness (63,6%), headache (54,4%), fever (50%), signs of pyramidal lesions. Cerebrospinal fluid showed increased white blood cell count (>5/mm³) 90,9%. Almost MRI showed bilateral lesions in subcortical white matter, frontal lobes: 63,6%, parietal lobes: 59,1%, temporal lobes: 36,4%. Conclusion: The main manifestations of ADEM with antibodies to MOG are altered consciousness, multifocal neurological symptoms, almost cases increase white blood cell in cerebrospinal fluid, frontal lobe lesions are the most common on MRI.