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Date Published: 25/09/2023
Abstract Views: 264
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DOI: https://doi.org/10.51298/vmj.v530i1B.6672
Issue
Vol. 530 No. 1B (2023)
Section
Các bài báo
How to Cite
Nguyễn, T. T. H., Nguyễn, H. T., Tạ, M. H., & Vũ, V. T. (2023). EFFECTS OF LOW DOSE KETAMINE COMBINED PROPOFOL-TCI ON HEMODYNAMIC DURING INDUCTION FOR ELDERLY PATIENTS. Vietnam Medical Journal, 530(1B). https://doi.org/10.51298/vmj.v530i1B.6672

EFFECTS OF LOW DOSE KETAMINE COMBINED PROPOFOL-TCI ON HEMODYNAMIC DURING INDUCTION FOR ELDERLY PATIENTS

Thị Thu Hà Nguyễn1,, Hữu Tú Nguyễn1, Minh Hiền Tạ1, Văn Trịnh Vũ2
1 HMU
2 GERMANY FRIENDSHIP HOSPITAL

Main Article Content

Abstract

Introduction: Hemodynamic instability has been a problem to concern in elderly patients, especially during induction. Various methods have been recommended to prevent that including TCI propofol. This studies effects of Propofol-TCI combined with low dose ketamine in induction for elderly under general anesthesia. Patients and methods: Sixty patients aged 60 or more years old with ASA I or II were divided randomly into two groups to receive either Propofol-TCI (group I) or Propofol-TCI combined with ketamine (0,5mg/kg; administered 2 minutes before propofol; group II). Heart rate, blood pressure, bispectral index (BIS) and TOF were recorded every 1minute. Fentanyl (2µg/kg); atracurium (0,8mg/kg) were given after target concentration defined. Intubation was performed after TOF=0. Results: The number of patients having severe hypotension was significantly lower in group II (low dose ketamine combined Propofol –TCI) and total dose of ephedrine as well, with p < 0,05. The heart rate was more stable than the one in control group.

Article Details

Keywords

Elderly anesthesia; ketamine, TCI-propofol, induction induced hypotension

References

1. Reich DL, Hossain S, Krol M, et al. (2005). Predictors of hypotension after induction of general anaesthesia. Anesth Analg; 101: 622–8.
2. Kanonidou Z, K.G., (2007) Anesthesia for the elderly.Hippokratia Hospital Greece. 11(4):p. 175-177.
3. Frölich, M.A., et al. (2005) Precision and bias of target controlled propofol infusion for sedation. British Journal of Anaesthesia. 94(4): p. 434-437.
4. Masui K, Kira M, Kazama T, Hagihira S, Mortier EP, Struys MMRF. (2002). Early phase pharmacokinetics but not pharmakodynamics are influenced by propofol infusion rate. Anesthesiology, 111, 805–17.
5. Larsen R, Rathgeber J, Bagdahn A, Lange H, Rieke H. (1988). Effects of propofol on cardiovascular dynamics on coronary blood flow in geriatric patients - A comparison with etomidate. Anaesthesia, 43(Suppl.), 25–31.
6. Fryer M. (2004). Intravenous induction agents. Anaesth Intensive Care Med, 5, 317–21.
7. Sylvie Passot, MD. (2000). A comparison of target- and manually controlled infusion propofol and etomidat/desflurane anesthesia in elderly patients undergoing hip fracture surgery. Anesth Analg, 100(1), 1338–42.
8. Đỗ Ngọc Hiếu (2012). Đánh giá sự thay đổi một số chỉ số huyết động và thời gian chờ đặt nội khí quản khi khởi mê sử dụng propofol-tci hoặc etomidate ở người cao tuổi. Luận văn Thạc sỹ y học, Trường đại học Y Hà Nội, Hà Nội.
9. Erdogan M, et al. (2013). Comparison of effects of propofol and ketamin-propofol mixture (ketofol) on laryngeal mask airway insertion conditions and hemodynamics in elderly patients: a randomized, prospective, double-blind trial. J Anesth. 27:12-17.