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COST-EFFECTIVENESS ASSESSMENT FOR INSULINE GLARGINE AND DETEMIR ON DIABETES MELLITUS TYPE 2 PATIENTS IN VIETNAM
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Abstract
Background and Objectives: Type 2 diabetes mellitus prevalence and mortality is increasing rapidly in recent years. Analog long-acting basal insulin is one of the most important diabetes treatment regimens in Vietnam. This study was conducted to assess the cost-effectiveness of two insulin analogs available in Vietnam: insulin glargine compared to insulin detemir when using for diabetes mellitus type 2 (T2DM) patients in Vietnam, based on published literature. Methods: A decision tree model was developed to assess the associated cost and utility when a patient uses insulin glargine or detemir and their risks of T2DM complications: Myocardial infarction, Stroke, Peripheral diseases and Severe hypoglycemia. Transitional probabilities, costs and utility are adjusted based on the mean %HbA1c reduction and probability of controlling blood glucose (%HbA1c ≤ 7%) for each insulin. Results: Insulin glargine is cost-effective compared to insulin detemir, with lower cost (saving 1,853,848 VND/patient/year) and gaining additional utility (0.008 QALY/patient/year). Conclusions: The study provides the evidence for insulin glargine’s cost-effectiveness when compared to insulin detemir for T2DM treatment in Vietnam.
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Keywords
diabetes mellitus type 2, cost – effectiveness, insulin glargine, insulin detemir
References
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