NGHIÊN CỨU NỒNG ĐỘ SEROTONIN DỊCH NÃO TỦY VÀ MỐI LIÊN QUAN VỚI MỘT SỐ BIỂU HIỆN LÂM SÀNG Ở BỆNH NHÂN MẮC BỆNH PARKINSON

Abstract

Objectives: To review the cerebrospinal fluid concentration of serotonin in patients with Parkinson’s disease and its correlation with clinical features. Subjects and methods:  A  prospective, cross-sectional study of  61  patients diagnosed with Parkinson’s disease and 40 healthy people with the corresponding age, sex. Quantitative assay of cerebrospinal fluid serotonin concentration for patients group and controls group was done. Results: The mean age of the patient’s group was 63.18 ± 9.46 years old; the control group was 61.77 ± 9.53 years old. There was no significant difference between the patient’s group and the controls group with p>0.05. The mean of serotonin concentration in cerebrospinal fluid of Parkinson patients group (175.63± 139.91pg/ml) was significantly lower than that in the control group (398.60 ± 267.93 pg/ml) with p<0.001, there was a negative correlation between the cerebrospinal fluid serotonin concentration and duration of disease with correlated coefficients r = - 0.649. The level of serotonin in cerebrospinal fluid in the patients group decreased gradually according to the level of disease, the stage of disease, the level of depression. The mean of serotonin concentration in cerebrospinal fluid of Parkinson patients group with cognitive impairment (101.81 ± 45.00 pg/ml) was significantly lower than that in Parkinson patients group without cognitive impairment (214.39 ± 156.85 pg/ml). Conclusion: Our study recognizes that decreased significantly cerebrospinal fluid serotonin levels of patients group and control group. The longer the duration of the disease was, the more the level cerebrospinal of serotonin decreased. It decreased significantly cerebrospinal fluid serotonin levels of Parkinson patients group with cognitive impairment and Parkinson patients group without cognitive impairment