NGHIÊN CỨU ĐẶC ĐIỂM LỚP SỢI THẦN KINH VÀ TẾ BÀO HẠCH HOÀNG ĐIỂM Ở TRẺ EM TẠI BỆNH VIỆN MẮT HÀ ĐÔNG

Abstract

DONG EYE HOSPITAL

Objective: To study the characteristics of nerve fiber layer and macular ganglion cells in children at Ha Dong Eye Hospital and related factors. Research method: Cross-sectional descriptive study at Ha Dong Eye Hospital on children aged 6-18 years, with refractive error of -3.00D to +3.00D and/or astigmatism < -2.00D. Exclusion criteria included strabismus, amblyopia, history of ocular diseases, family history of glaucoma, findings of corneal and macular abnormalities. Only reliable OCT Cirrus HD-OCT 5000 results (signal strength > 6/10) were selected for analysis. Results: The study group included 105 eyes of 55 children aged 6-18 years, with the following results: Mean age was 13.63 ± 2.87. The average thickness of the nerve fiber layer was 114.25 ± 21.90 µm, of which 89.5% had a thickness > 90 µm. The nerve fiber layer thickness decreased from superior (S): 136.90 ± 37.14 µm > inferior (I) 137.38 ± 37.19 µm > temporal (T) 95.52 ± 25 µm > nasal (N) 89.31 ± 27.61 µm. The average cup volume was 10.10 ± 0.75 mm3 with an average cup depth of 279.81 ± 22.47 µm. The overall average thickness of the ganglion cell-inner plexiform layer (GC-IPL) was 84.22 ± 15.71 µm. The highest thickness was in the superior temporal region and the lowest was in the inferior region. The thinnest part of ILM-PRE was in the central region, with the thinnest being in the outer ring region. The highest average thickness of ILM-PRE in the upper inner region and ILM-PRE in the lower inner region were 314.16 ± 20.79 µm and 308.22 ± 24.90 µm, respectively. The two regions with the lowest average thickness were ILM-PRE in the outer lower region with 271.31 ± 20.11 µm and ILM-PRE in the central region with 233.81 ± 30.40 µm. Conclusion: The study on 105 eyes has collected normal values for GC-IPL, RNFL, and cup volume in Vietnamese children. The results help identify changes in GC-IPL and RNFL thickness in children. The peripheral region area is related to RNFL thickness, while gender and refractive status are related to macular ganglion thickness. GC-IPL thickness is not affected by other factors and can be used for diagnosing and monitoring glaucoma pathology in children.