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EFFECTIVENESS OF LIPOSOMAL DOXORUBICIN IN THE TREATMENT OF RECURRENT OR METASTASIS ENDOMETRIAL CANCER AT K HOSPITAL
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Abstract
Objectives: This study aims to evaluate overall response rate and progression free survival of pegylated liposomal doxorubicin (PLD) in patients with recurrent/ metastasis endometrial cancer. Materials and methods: This non – interventional observational study used medical record of patients diagnosed with recurrent/ metastasis endometrial cancer who received PLD at National Cancer Hospital from June 2017 to June 2023. Baseline characteristics, PLD dose, treatment reponse and progression free survival were extracted. Results: A total of 56 patients with recurrent/ metastasis endometrial cancer were included in this study. 11 of 56 (19.7%) patients had an objective response, of which 3 (5.4%) were complete response and 8 (14.3%) achieved partial response. Stable disease was seen in 29 patients (51.8%), and 16 patients (28.5%) had disease progression. Median progression free survival was 18.3 weeks. Conclusions: Liposomal doxorubicin monotherapy is effective in recurrent/ metastasis endometrial cancer patients.
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Keywords
Recurrent/ metastasis endometrial cancer; liposomal doxorubicin.
References
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