Article Sidebar

pdf
Date Published: 25/09/2023
Abstract Views: 116
Views pdf: 109
DOI: https://doi.org/10.51298/vmj.v530i1B.6756
Issue
Vol. 530 No. 1B (2023)
Section
Các bài báo
How to Cite
Nguyễn, X. H., Nguyễn, V. C., Phạm, T. P., & Nguyễn, Q. D. (2023). SOME RESULTS OF RESEARCH ON THE EFFECTS OF PH EXTRACT ON AN EXPERIMENTAL MODEL OF ULCERATIVE COLITIS. Vietnam Medical Journal, 530(1B). https://doi.org/10.51298/vmj.v530i1B.6756

SOME RESULTS OF RESEARCH ON THE EFFECTS OF PH EXTRACT ON AN EXPERIMENTAL MODEL OF ULCERATIVE COLITIS

Xuân Huấn Nguyễn1,, Văn Cường Nguyễn1, Thị Phượng Phạm1, Quang Duật Nguyễn2
1 Military Institute of Traditional Medicine
2 Vietnam Military Medical Academy

Main Article Content

Abstract

The study applied rat ulcerative colitis model induced by TNBS/ Ethanol according to Morris to evaluate the therapeutic effects of PH with Pentasa. Results: PH with Pentasa showed significant improvement in the anatomical and histological structure of large intestinal mucosal, clinical disease activity index include Wallcea, Neurath, Vilaseca in PH with Pentasa group were no statistically significant difference compared to control group (P>0.05), but were significant difference compared with the vehicle group and the monotherapy group (P<0.05). Conclusion: PH extract combined with Pentasa has the effect of improving the treatment effectiveness of ulcerative colitis.

Article Details

Keywords

PH extract, UC, experimental.

References

Nguyễn Thị Thu Hiền, Đào Văn Long, Đặc điểm lâm sàng và cận lâm sàng bệnh viêm loét đại trực tràng chảy máu. Tạp chí nghiên cứu y học,2010.66(1): 69-75.
2. Bộ Y tế, Phương pháp nghiên cứu tác dụng của thuốc từ thảo dược, NXB Y học, 2006.
3. Bộ Y tế, Quyết định 141/QĐ-K2ĐT ngày 27 tháng 10 năm 2015 “Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu”,2015.
4. WHO, General guidelines for methodologies on research and evaluational of tradition medicine, World Health Organization, 2001. https:// www.who.int/ publications/i/item/9789241506090
5. Morris, G. P., Beck, P. L., Herridge, M. S., Depew, W. T., Szewczuk, M. R., & Wallace, J. L, Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology, 1989, 96(3): 795-803. https://doi.org/10.1016/0016-5085(89)90904-9
6. Wallace, J. L., McKnight, W., Asfaha, S., & Liu, D. Y., Reduction of acute and reactivated colitis in rats by an inhibitor of neutrophil activation. American Journal of Physiology-Gastrointestinal and Liver Physiology. Am. J. Physiol, 1998, 274(5): G802–G808. https:// doi.org/ 9612259
7. Wirtz, S., Neurath, M., Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease. Int J Colorect Dis, 2000,15,144–160. https:// doi.org/ 10.1007/ s003840000227
8. Vilaseca, J., Salas, A., Guarner, F., Rodriguez, R., & Malagelada, J. , Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis. Gastroenterology, 1990,98(2), 269-277. https:// doi.org/ 10.1016/ 0016-5085(90)90814-H