CLINICAL AND PARA-CLINICAL CHARACTERISTICS AND THE EFFECTIVENESS OF PHOTOTHERAPY IN NEONATES WITH INDIRECT HYPERBILIRUBINEMIA JAUNDICE AT CAN THO

Quang Khải Trần1,, Minh Phương Nguyễn1, Quang Nghĩa Bùi1, Thị Mỹ Liên Nguyễn1, Đức Trí Nguyễn2, Mạnh Cường Nguyễn3
1 Can Tho University of Medicine - Pharmacy
2 Can Tho Children's Hospital
3 Hospital 103, Military Medical Academy

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Abstract

Objectives: To describe the clinical, para-clinical characteristics and evaluate of the effectiveness of phototherapy in neonates with indirect hyperbilirubinemia jaundice at the Neonatal Department, Can Tho Children’s Hospital. Methods: Cross-sectional descriptive study on 121 infants with indirect hyperbilirubinemia jaundice and used phototherapy as the treatment at Can Tho Children’s Hospital from June 2021 to June 2022. Results: Male sex accounted for 50.4%, with a male/female ratio was 1.02, premature infant rate of 17.4%. There were 35.5% of infants with zone 5 jaundice according to Kramer, mainly seen in premature infants. The average indirect bilirubin concentration was 274.4±78.4 µmol/l. Indirect bilirubin was higher in infants born vaginally than those born by surgery, with comorbidities higher than those without comorbidities (p<0.05). Treatment results: 96.7% of neonates were successfully cured, 3.3% failed and had to exchange transfusion. Infants with comorbidities, had jaundice in zone 5, were born vaginally, jaundice appeared before 7 age day, prolonged phototherapy exposure time. Conclusion: Phototherapy in neonates of indirect hyperbilirubinemia with was highly effective; it needs to focus on infants with infection diseases, jaundice appeared soon in order

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References

1. Alkén J, Håkansson S, Ekéus C, Gustafson P, Norman M. Rates of Extreme Neonatal Hyperbilirubinemia and Kernicterus in Children and Adherence to National Guidelines for Screening, Diagnosis, and Treatment in Sweden. JAMA network open. 2019;2(3):e190858.
2. Nguyễn Thị Thanh Bình, Trần Thị Phương Thảo, Phan Hùng Việt. Nghiên cứu đặc điểm lâm sàng và cận lâm sàng của vàng da tăng bilirubin gián tiếp ở trẻ sơ sinh. Tạp chí Y Dược học - Trường Đại học Y Dược Huế. 2017;7(1):84-89.
3. Mitra S, Rennie J. Neonatal jaundice: aetiology, diagnosis and treatment. British journal of hospital medicine (London, England : 2005). 2017; 78(12):699-704.
4. Dipak Kumar, et al. A Prospective Investigation of the Aetiology and Clinical Characteristics of Newborn Jaundice in Bihar, India. International Journal of Pharmaceutical and Clinical Research. 2021;13(4):272-276.
5. Khairy MA, Abuelhamd WA, Elhawary IM, Mahmoud Nabayel AS. Early predictors of neonatal hyperbilirubinemia in full term newborn. Pediatr Neonatol. 2019;60(3):285-290.
6. Bùi Thị Bạch Huệ, Nguyễn Thanh Đại. Đánh giá hiệu quả và an toàn trong chiếu đèn và truyền máu trẻ vàng da tán huyết tại Bệnh viện Phụ Sản Quốc tế Sài Gòn Tạp chí Y học TP Hồ Chí Minh. 2010;14(4):1-5.
7. Viau Colindres J, Rountree C, Destarac MA, et al. Prospective randomized controlled study comparing low-cost LED and conventional phototherapy for treatment of neonatal hyperbilirubinemia. J Trop Pediatr. 2012;58(3):178-183.