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Date Published: 06/10/2023
Abstract Views: 144
Views pdf: 100
DOI: https://doi.org/10.51298/vmj.v530i2.6797
Issue
Vol. 530 No. 2 (2023)
Section
Các bài báo
How to Cite
Phạm, V. T., Trần, N. D., Nguyễn, T. L., Đặng, T. C., & Vũ, P. T. (2023). A STUDY ASSESSING THE RELATIONSHIP BETWEEN TUMOR BUDDING AND HISTOPATHOLOGICAL FEATURES IN GASTRIC CANCER. Vietnam Medical Journal, 530(2). https://doi.org/10.51298/vmj.v530i2.6797

A STUDY ASSESSING THE RELATIONSHIP BETWEEN TUMOR BUDDING AND HISTOPATHOLOGICAL FEATURES IN GASTRIC CANCER

Văn Thịnh Phạm1, Ngọc Dũng Trần1, Thùy Linh Nguyễn1, Thành Chung Đặng1,, Phương Thảo Vũ2
1 103 Military Hospital
2 Vietnam Military Medical Academy

Main Article Content

Abstract

Objectives: to determine the rate of tumor budding in gastric carcinoma patients and evaluate its relationship with certain general and histopathological characteristics. Subjects and methods: a retrospective, cross-sectional study that included 87 patients diagnosed with gastric cancer at 103 Military Hospital from January 2020 to March 2023. The histopathological characteristics were examined, and the collected data was analyzed to determine the association between the obtained indicators. Results: The majority of tumors were tubular-papillary carcinoma (49.43%) and had moderate to low differentiation (85.06%). Lauren intestinal carcinoma was the most common type. Most of the subjects exhibited tumor cells that had infiltrated the muscular layer (pT2), and 42.53% displayed metastasis in the lymph nodes. The occurrence of vascular and neurological invasion was infrequent. Furthermore, a significant proportion of cases demonstrated high-grade tumor budding (51.72%). A statistically significant association was found between high-grade tumor budding and characteristics of poorly cohesive carcinoma and poorly differentiated carcinoma (WHO 2019), high degree of pT invasiveness, low differentiation, and potential for lymph node metastasis of tumor cells. Conclusion: Tumor budding is a microscopic feature that has prognostic value in assessing invasion and metastasis in gastric cancer. This study highlights the importance of evaluating tumor budding in gastric cancer patients to help predict disease progression and determine appropriate treatment strategies.

Article Details

Keywords

gastric carcinoma, tumor budding.

References

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