RESEARCH FOR CLINICAL FEATURES IN PATIENTS WITH GLIOBLASTOMA

Anh Đức Trần1, Thành Bắc Nguyễn1, Đức Liên Nguyễn2, Quang Hùng Ngô3,
1 Military Hospital 103, Military Medical Academy
2 K Hospital - Tan Trieu
3 Saint Paul general hospital

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Abstract

Objectives: Describe the clinical characteristics in patients with glioblastoma at National Cancer Central Hospital. Subjects and methods: cross-sectional tissue study on 34 glioblastoma patients undergoing surgery, laboratory tests and combined chemotherapy and radiotherapy at National Cancer Central Hospital, Tan Trieu campus. Tide from January 2019 to December 2020. Results: the average age of patients was 46.8 ± 15.6 years old; the age group 40-59 years accounted for the majority (over 50%). Men accounted for the majority, with 70.6%. Patients often came to the hospital early due to the rapidly progressing disease, diagnosed within one month, accounting for 52.9%, 1-3 months, accounting for 41.2%, with the main reason for admission to the hospital as headache (88.2%). The patient's condition on admission showed that over 70% of cases had Karnofsky scores <60 points. Conclusion: Glioblastoma with disease age is usually over 40, and the time to detect the disease is usually early, with the main reason for hospitalization being a headache. Patients at the time of admission often begin to have physical deterioration.

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References

1. Louis DN, Perry A, Reifenberger G . (2016). The 2016 World Health Organization classifcation of tumors of the central nervous system: a summary. Acta Neuropathol 131: 803-820.
2. Ohgaki H, Kleihues P (2005). Epidemiology and etiology of gliomas. Acta Neuropathol, 109(1): 93-108.
3. Ostrom QT, Gittleman H, Stetson L. (2015). Epidemiology of gliomas. Cancer Treat Res, 163: 1-14.
4. Trần Kim Tuyến (2022), Nghiên cứu đột biến gen IDH1/2 của u tế bào thần kinh đệm lan tỏa ở người trưởng thành, Luận án tiến sĩ y học, Đại học Y Dược thành phố Hồ Chí Minh.
5. Hoàng Minh Đỗ (2009), Nghiên cứu chẩn đoán và thái độ điều trị u não thể glioma ở bán cầu đại não, Luận án tiến sĩ Y học, Học viện Quân Y.
6. Y. Narita, S. Shibui (2015). Trends and outcomes in the treatment of gliomas based on data during 2001–2004 from the Brain Tumor Registry of Japan. Neurologia medico-chirurgica, 55 (4): 286-95.
7. Trần Chiến (2011), Nghiên cứu đặc điểm lâm sàng, chẩn đoán hình ảnh và kết quả phẫu thuật u não tế bào thần kinh đệm hình sao Astrocytoma vùng bán cầu đại não, Luận án tiến sĩ Y học, Đại học Y Hà Nội.
8. A. M. Molinaro, J. W. Taylor, J. K. Wiencke, et al. (2019). Genetic and molecular epidemiology of adult diffuse glioma. Nature Reviews Neurology, 15(7): 405-417.