ĐÁNH GIÁ HIỆU QUẢ GIẢM ĐAU CẤP SAU MỔ CỦA NEFOPAM KẾT HỢP DICLOFENAC TRONG PHẪU THUẬT NỘI SOI KHỚP GỐI

Abstract

Background: Multimodal pain management using a combination of non-opioid analgesics can provide more effective pain relief, reduce the side effects of opioids, and shorten recovery time, especially in orthopaedic surgery. Objectives: To evaluate the postoperative analgesic effects of combination of nefopam and diclofenac compared with nefopam in knee arthroscopic. Subjects and Methods: This randomized, controlled clinical trial was conducted on 90 patients who underwent knee arthroscopy. Patients were enrolled and divided into two groups: the first group received nefopam plus diclofenac and the second group received nefopam alone. Evaluation of the analgesic effect by total morphine rescue dose in the first 24 h after surgery. Pain scores on the VAS scales at rest and during movement, as well as side effects were also recorded. Results: The median total morphine rescue dose in the first 24 h after surgery was significant different between the intervention (0 mg) and control (3 mg) groups (p = 0.001). The VAS scores at rest and during movement at 3, 6, 12, and 24 h after surgery in the intervention group were statistically significant compared with those in the control group (p < 0.05). Adverse effects were similar in both the groups. Conclusion: The combination of nefopam and diclofenac was effective in reducing pain in patients undergoing arthroscopic knee surgery. No serious adverse effects were observed.