MỐI LIÊN QUAN GIỮA BIẾN THỂ GEN AGTR1 A1166C VÀ CÁC YẾU TỐ NGUY CƠ BỆNH MẠCH VÀNH Ở BỆNH NHÂN NHỒI MÁU CƠ TIM CẤP

Abstract

Objectives: To investigate the association of AGTR1 A1166C genetic polymorphism with coronary artery disease risk factors in patients with acute myocardial infarction (AMI). Subjects and methods:  We conducted a cross-sectional, descriptive study on AMI patients at the Department of Cardiology and Department of Interventional Cardiology, Cho Ray Hospital from January 2020 to January 2021. The polymerase chain reaction test to determine the genotypes of the AGTR1 A1166C was performed at the Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City. Results: This study included 414 patients with first AMI. The mean age of participants was 63.8 ± 11.6 and males accounted for 71.0%. Dyslipidemia (89.4%) and hypertension (79.5%) were the most common coronary artery disease risk factors. The proportions of AA, AC, and CC were 90.3, 9.2%, and 0.5%, respectively. AA, AC, and CC genotypes were not associated with coronary artery disease risk factors in the overall study population and in subgroups by gender, age, and clinical type of AMI. Conclusion: AGTR1 A1166C genetic polymorphism is not associated with coronary artery disease risk factors in patients with first AMI.