CLINICAL CHARACTERISTICS AND RISK FACTORS FOR SEVERITY OF COVID-19 IN OVERWEIGHT AND OBESITY PATIENTS

Minh Nhựt Vương1,, Tuấn Long Nguyễn2, Thị Hiếu Vũ3, Triều Lý Võ 1,2
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 Hospital for Tropical Diseases
3 Pham Ngoc Thach Hospital

Main Article Content

Abstract

Background: COVID-19 is a global pandemic with high mortality rate. One of the risk factors for severe COVID-19 is overweight, obesity. These conditions affect the inflammatory response to SARS-COV-2, triggering a cytokine storm. In addition, the comorbidities such as hypertension and diabetes are also risk factors for severity and high mortality in COVID-19 patients. Objectives: (1) Describe clinical performances, investigations and severity of overweight and obesity COVID-19 patients in Hospital of Tropical diseases; (2) Identify risk factors for severity in overweight and obesity COVID-19 patients in Hospital of Tropical diseases. Result: A descriptive cross-sectional study. From July 2021 to December 2021, there were 173 eligible patients, 70 (10.4%) overweight cases, 74 (42.8%) grade I obesity, 29 (16.8%) grade II obesity. The most common clinical symptoms: cough – 153/173 (88.4%), dyspnea – 127/172 (73.3%), and fever – 121/172 (69.9%). 26.6% of the patients were leukocytosis, 53.8% of the population were lymphocytopenia (below 1.0 K/mL), 33% of the patients reported to have cytokine storm. The proportion of critical, severe, moderate, and mild disease was 8.1%, 68.8%, 13.9% and 9.2%, respectively. Risk factors for the severity of COVID-19 were grade II obesity (OR = 10,63 (1,34 – 84,05)) and hypertension (OR = 2,16 (1,03 – 4,56)). Conclusions: Obesity was the risk factor for severity of COVID-19.

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References

Bộ Y tế, Quyết định về việc ban hành hướng dẫn chẩn đoán và điều trị COVID-19, 2021: Hà Nội.
2. Võ Thanh Lâm, "Đặc điểm dịch tễ, diễn tiến lâm sàng và cận lâm sàng ở người nhiễm SARS-CoV-2 tại thành phố Hồ Chí Minh năm 2020", Đại học Y Dược TPHCM 2021.
3. Rottoli Matteo, Bernante Paolo, Belvedere Angela, Balsamo Francesca, Garelli Silvia, et al., "How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre %J European Journal of Endocrinology". 2020, 183 (4), pp. 389-397.
4. Hamer Mark, Gale Catharine R., Kivimäki Mika, Batty G. David, "Overweight, obesity, and risk of hospitalization for COVID-19: A community-based cohort study of adults in the United Kingdom". Proceedings of the National Academy of Sciences, 2020, 117 (35), pp. 21011.
5. Hu Z., Huang X., Zhang J., Fu S., Ding D., et al., "Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients". Front Med (Lausanne), 2021, 8, pp. 792135.
6. Ramatillah D. L., Gan S. H., Pratiwy I., Syed Sulaiman S. A., Jaber A. A. S., et al., "Impact of cytokine storm on severity of COVID-19 disease in a private hospital in West Jakarta prior to vaccination". PLoS One, 2022, 17 (1), pp. e0262438.
7. Yang Jun, Hu Jiahui, Zhu Chunyan, "Obesity aggravates COVID-19: A systematic review and meta-analysis". 2021, 93 (1), pp. 257-261.
8. Alegre-Díaz Jesus, Friedrichs Louisa G, Ramirez-Reyes Raul, Wade Rachel, Bragg Fiona, et al., "Body mass index and COVID-19 mortality: prospective study of 120 000 Mexican adults". International Journal of Epidemiology, 2022, 51 (5), pp. 1698-1700.