Article Sidebar

pdf
Date Published: 06/10/2023
Abstract Views: 159
Views pdf: 217
DOI: https://doi.org/10.51298/vmj.v530i2.6850
Issue
Vol. 530 No. 2 (2023)
Section
Các bài báo
How to Cite
Nguyễn, P. A. (2023). THE PREVALENCE OF BCP/PC MUTATIONS WERE ASSOCIATED WITH LIVER CIRRHOSIS (LC) AND HEPATOCELLULAR CARCINOMA (HCC) IN CHRONIC HEPATITIS B PATIENTS WITH HCC AT NATIONAL CANCER HOSPITAL, HANOI. Vietnam Medical Journal, 530(2). https://doi.org/10.51298/vmj.v530i2.6850

THE PREVALENCE OF BCP/PC MUTATIONS WERE ASSOCIATED WITH LIVER CIRRHOSIS (LC) AND HEPATOCELLULAR CARCINOMA (HCC) IN CHRONIC HEPATITIS B PATIENTS WITH HCC AT NATIONAL CANCER HOSPITAL, HANOI

Phương Anh Nguyễn1,
1 Hanoi National Cancer Hospital

Main Article Content

Abstract

Objective: to investigate HBV BCP/PC mutations were associated with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients with HCC at Vietnam National Cancer Hospital, Hanoi. Methods: The BCP/PC mutations were significantly associated with LC and HCC in 40 chronic hepatitis B patients with HCC at Vietnam National Cancer Hospital, Hanoi, from January 2017 to December 2019 were investigated by direct sequencing on 3130XL Genetic analyzer ABI. Results: Seven mutations in the BCP/PC region associated with cirrhosis in chronic hepatitis B patients with HCC include A1726C, A1727T, C1730G/A, C1766T, T1768A, C1773T and C1799G. Eight mutations in the BCP/PC region associated with HCC in CHB patients with HCC include T1753V, A1762T, G1764A, A1846T, G1896A and G1899A, A1762T/G1764A và A1762T/G1764A + T1753V (C/A/G/del). The frequency of mutations varies depending on the genotype, in general, the frequency of mutations associated with cirrhosis and HCC is higher in genotype B than in genotype C. Conclusions: Seven mutations in the BCP/PC region associated with cirrhosis in CHB patients with HCC include A1726C, A1727T, C1730G/A, C1766T, T1768A, C1773T and C1799G. Eight mutations in the BCP/PC region associated with HCC in CHB patients with HCC include T1753V, A1762T, G1764A, A1846T, G1896A and G1899A, A1762T/G1764A và A1762T/G1764A + T1753V (C/A/G/del).

Article Details

References

1. Jang JW, Chun JY, Park YM, Shin SK, Yoo W, Kim SO, Hong SP. Mutational complex genotype of the hepatitis B virus X/precore regions as a novel predictive marker for hepatocellular carcinoma. Cancer Sci 2012 Feb; 103(2): 296-304.
2. Liao Y, Hu X, Chen J, Cai B, Tang J, Ying B, Wang H, Wang L. Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis. PLoS One 2012; 7(6): e38394.
3. Ligat G, Schuster C, Baumert TF. Hepatitis B Virus Core Variants, Liver Fibrosis, and Hepatocellular Carcinoma. Hepatol (Baltimore, Md) 2019 Jan 01; 69(1): 5-8.
4. Nguyễn Nghiêm Luật, Nguyễn Hữu Quyền, Đặng Văn Tản, Vũ Mạnh Hồng, Nguyễn Thị Thu Hương, Võ Ngọc Lan, Phạm Hùng Vân. Các đột biến trên vùng BCP/PC của virus viêm gan B có liên quan đến xơ gan và ung thư tế bào gan được phát hiện ở bệnh nhân viêm gan B mạn ở miền Bắc Việt Nam. Tạp chí Gan mật Việt Nam 2013; 25: 13-19.
5. Park YM. Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome. World J Hepatol 2015 Jan 27; 7(1): 113-120.
6. Yin J, Xie J, Liu S, Zhang H, Han L, et al. Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. Am J Gastroenterol 2011 Jan; 106(1): 81- 92.
7. Zhang D, Ma S, Zhang X, Zhao H, Ding H, and Zeng C. Prevalent HBV point mutations and mutation combinations at BCP/preC region and their association with liver disease progression. BMC Infect Dis 2010; 10: 271.