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EFFECTIVENESS OF TOPICAL 5% CYSTEAMINE HYDROCHLORIDE IN MELASMA IN UNIVERSITY MEDICAL CENTER AT HO CHI MINH CITY
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Abstract
Objectives: To evaluate the clinical efficacy of topical 5% cysteamine hydrochloride in melasma in University Medical Center at Ho Chi Minh city. Material and methods: A descriptive study of a series of cases, longitudinal follow-up was conducted on 32 patients with melasma and indicated treatment with topical 5% cysteamine hydrochloride at Department of Dermatology and Skin Aesthetics – University Medical Center at Ho Chi Minh city from 8/2021 to 8/2023. Results: Among 32 patients in this research, all of them were female and the mean age was 43,9 ± 9,3. Fitzpatrick skin types were mostly type IV (71,9%) and type III (28,1%). Stratification of patients regarding severity led to 28,1% in the mild subgroup, 8% in the moderate subgroup, 18,8% in the severe subgroup and 28,1% in the very severe subgroup. After treatment with topical 5% cysteamine hydrochloride, 87,5% of patients reported satisfied or very satisfied with the results. mMASI improved after 1, 2 and 3 months (P = 0,06, 0,04 and 0,02, respectively). Skin analysis score using VISIA and Colorimeter also showed significant improvements. Changes of MELASQoL after 1, 2 and 3 months of treatment also reached statistical difference. About the safety of the method, “No abnormality” was the most common feedback from patients and doctors. Conclusion: Topical 5% cysteamine hydrochloride is an effective and safe method in the treatment of melasma.
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Keywords
cysteamine hydrochloride, melasma
References
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