ĐÁNH GIÁ ĐỘC TÍNH CẤP VÀ ẢNH HƯỞNG CỦA BÀI THUỐC “AN THẦN ĐỊNH TRÍ QY” ĐỐI VỚI THỂ TRẠNG CHUNG VÀ CÁC CHỈ SỐ HUYẾT HỌC TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objectives: To evaluate the acute toxicity on Swiss mice and the effects on the body, weight, and hematological indexes on Wistar rats of the "An than dinh tri QY" remedy. Methods: Acute toxicity was evaluated according to the Litchfield–Wilcoxon method. The effect of remedies on general condition and hematological indexes was evaluated according to WHO guidelines. Dosage in grams of dry herbs. Result: Swiss mice were administrated orally “An than dinh tri QY” with the doses to 375g/kg body weight in a day but no mice died or had any toxicity. On Wistar rats were administrated orally "An than dinh tri QY" for 28 days, with the dose of 21g/kg/day and 63g/kg/day, does not affect the general condition and hematological indexes. Conclusion: The "An than dinh tri QY" remedy was safe in acute toxicity assessment on Swiss mice, and did not affect the general condition and hematological indicators when given to Wistar rats continuously for 28 days.