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Date Published: 27/10/2023
Abstract Views: 294
Views PDF: 202
DOI: https://doi.org/10.51298/vmj.v531i1.6935
Issue
Vol. 531 No. 1 (2023)
Section
Các bài báo
How to Cite
Nguyễn , Đình T., Bồ , V. L. ., Lê, T. Đạt ., & Trần , T. T. . (2023). CLINICAL FEATURES AND SUB-CLINICAL OF ANTI-TUBERCULOSIS DRUG INDUCED LIVER INJURY WITH PATIENTS TREATED WITH FIRST-LINE ANTITUBERCULOSIS DRUGS IN PHAM NGOC THACH HOSPITAL. Vietnam Medical Journal, 531(1). https://doi.org/10.51298/vmj.v531i1.6935

CLINICAL FEATURES AND SUB-CLINICAL OF ANTI-TUBERCULOSIS DRUG INDUCED LIVER INJURY WITH PATIENTS TREATED WITH FIRST-LINE ANTITUBERCULOSIS DRUGS IN PHAM NGOC THACH HOSPITAL

Đình Thắng Nguyễn 1,, Văn Lâm Bồ 2, Thành Đạt Lê1, Thái Thụ Trần 1
1 Pham Ngoc Thach University of Medicine
2 Binh Duong Department of health

Main Article Content

Abstract

Objective: Describe clinical  features and sub-clinical of anti-tuberculosis drug induced liver injury with patients treated with first-line antituberculosis drugs in Pham Ngoc Thach Hospital. Subject  and  methods: This study describes a series of cases of all TB patients being treated with first-line anti-tuberculosis drugs admitted to Pham Ngoc Thach hospital from October 1, 2019 to June 30, 2020 diagnosed with AT-DILI in treatment phase. Results: In a total of 159 patients, the mean age was 51,4 ± 17,3 years old, the age group with a high percentage in the study was from 35 years old and above, with 81,8%. There were 60.4% patients with pulmonary tuberculosis alone, 20.8% had extrapulmonary tuberculosis and 18.8% had both pulmonary and extrapulmonary tuberculosis. The most common symptoms in patients with AT-DILI were jaundice, yellow eyes and nausea, with the rate of 54.6%, 48.7% and 47.4%, respectively. The number of HIV-infected patients in the study was 23/85, accounting for 27.1%, of which 3 patients had a history of ART (3.5%). There were 65.6% of patients tested for HBsAg and anti-HCV with positive rates of 5.9% and 6.9%, respectively. Conclusion: The disease is common in patients aged 35 years and over. The most common symptoms in patients with AT-DILI were jaundice, yellow eyes and nausea. TB patients diagnosed with AT-DILI have HIV co-infection or hepatitis B and/or C.

Article Details

Keywords

Tuberculosis, Anti-tuberculosis drug-induced liver injury.

References

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