CERVICAL EPITHELIOID TROPHOBLASTIC TUMOR: A RARE CASE REPORT

Thành Nhân Võ 1, Trọng Nhân Nguyễn 2,, Minh Văn Lưu 1
1 Tu Du hospital
2 Pham Ngoc Thach University of Medicine

Main Article Content

Abstract

Introduction: epithelioid trophoblastic tumor (ETT) represents an atypical variant within the spectrum of trophoblastic tumors, posing diagnostic challenges and subsequently complicating treatment decisions. Existing literature underscores the preference for surgical intervention as the primary therapeutic approach for ETT due to its limited responsiveness to chemotherapy, which is typically effective against other forms of gestational trophoblastic diseases. Case report: this case report describes a 51 years-old female patient admitting to the hospital due to vaginal bleeding and high level of beta human chorionic gonadotropin (β-hCG). The initial diagnosis was a choriocarcinoma of the cervix. Two cycles of chemotherapy was chosen before surgical management because of  tumor size and hypervascularization. The surgical procedure concluded with a minimal blood loss of 50 ml, and the patient was discharged without experiencing any adverse events. Conclusion: preoperative chemotherapy may prove effective in cases of ETT characterized by substantial tumor size and heightened vascularity, serving as a preventive measure against intraoperative blood loss.

Article Details

References

1. Dash S, Sakhadeo U, Karmarkar S, Mittal N, Menon S, Rekhi B, et al. Epithelioid trophoblastic tumor: A case series. Indian J Pathol Microbiol. 2023;66(1):148.
2. Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, et al. Diagnosis and management of gestational trophoblastic disease: 2021 update. Int J Gynecol Obstet. 2021 Oct;155(S1):86–93.
3. Li J, Shi Y, Wan X, Qian H, Zhou C, Chen X. Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases. Med Oncol. 2011 Mar;28(1):294–9.
4. Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. American Journal of Obstetrics and Gynecology. 2010 Dec;203(6):531–9.
5. Shih IM, Kurman RJ. The Pathology of Intermediate Trophoblastic Tumors and Tumor-like Lesions: International Journal of Gynecological Pathology. 2001 Jan;20(1):31–47.
6. Yang J, Fu LY, Zhang W, Wang Z. Mechanical property and thermal damage factor of limestone at high temperature. International Journal of Rock Mechanics and Mining Sciences. 2019 May;117:11–9.
7. Gadducci A, Carinelli S, Guerrieri ME, Aletti GD. Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy. Gynecologic Oncology. 2019 Jun;153(3):684–93.
8. Froeling FEM, Ramaswami R, Papanastasopoulos P, Kaur B, Sebire NJ, Short D, et al. Intensified therapies improve survival and identification of novel prognostic factors for placental-site and epithelioid trophoblastic tumours. Br J Cancer. 2019 Mar;120(6):587–94.
9. Frijstein MM, Lok CAR, van Trommel NE, ten Kate-Booij MJ, Massuger LFAG, van Werkhoven E, et al. Management and prognostic factors of epithelioid trophoblastic tumors: Results from the International Society for the Study of Trophoblastic Diseases database. Gynecologic Oncology. 2019 Feb;152(2):361–7.
10. Yang C, Li J, Zhang Y, Xiong H, Sheng X. Epithelioid trophoblastic tumor coexisting with choriocarcinoma around an abdominal wall cesarean scar: a case report and review of the literature. J Med Case Reports. 2020 Dec;14(1):178.
11. Arafah MA, Tulbah AM, Al-Husaini H, Al-Sabban M, Al-Shankiti H, Al-Badawi IA. Extrauterine Epithelioid Trophoblastic Tumor Arising in the Ovary With Multiple Metastases: A Case Report. Int J Surg Pathol. 2015 Jun;23(4):339–44.