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Date Published: 27/10/2023
Abstract Views: 78
Views PDF: 71
DOI: https://doi.org/10.51298/vmj.v531i1.6956
Issue
Vol. 531 No. 1 (2023)
Section
Các bài báo
How to Cite
Trần, A. Đức ., Nguyễn , Đức L. ., Ngô , Q. H. ., & Nguyễn , T. B. . (2023). CLINICAL AND PARACLINICAL CHARACTERISTICS IN PATTERNS WITH GRADE III GLIOMA. Vietnam Medical Journal, 531(1). https://doi.org/10.51298/vmj.v531i1.6956

CLINICAL AND PARACLINICAL CHARACTERISTICS IN PATTERNS WITH GRADE III GLIOMA

Anh Đức Trần1, Đức Liên Nguyễn 2, Quang Hùng Ngô 3, Thành Bắc Nguyễn 1,
1 103 Military Hospital, Vietnam Military Medical Academy
2 k hospital
3 Xanh Pon hospital

Main Article Content

Abstract

Objectives: To describe the clinical and subclinical characteristics of patients with grade III glioma at K Central Hospital. Subjects and methods: Cross-sectional tissue study on 18 patients with grade III glioma undergoing surgery, performing subclinical tests at K Central Hospital, Tan Trieu campus, from January 2019 to December 2020. Results: the mean age of patients was 42.1 ± 11.4 years old. The proportion of men is higher than that of women (55.6%). The main symptoms of patients are headache (88.9%), nausea and vomiting (22.2%), dizziness (22.2%), and hemiplegia (16.7%). On admission, 61.1% of cases had Karnofsky scores>80 points. The rate of IDH gene mutation in the studied patients was 66.7%. Conclusion: Glioblastoma grade III is usually over 40 years old; the main symptoms are headache, nausea, and vomiting. Patients on admission are generally in good condition. IDH gene mutations often occur in grade III gliomas at a high rate.

Article Details

Keywords

grade III glioma, anaplastic astrocytoma anaplastic oligodendroglioma.

References

1. Quinn T. Ostrom, Haley Gittleman, Jordan Xu, et al. (2016). CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009–2013. Neuro-Oncology, 18(suppl_5): v1-v75.
2. Esperanza GM Roberto GN, Alfonso MB, Julio Sd (2011), Biological Markers of Recurrence and Survival of High-Grade Gliomas: The Role of Hepatocyte Growth Factor, Glioma in Exploring Its Biology and Practical Relevance, Dr. Anirban Ghosh, Editor InTech, 37-48.
3. Trần Kim Tuyến (2022), Nghiên cứu đột biến gen IDH1/2 của u tế bào thần kinh đệm lan tỏa ở người trưởng thành, Luận án tiến sĩ y học, Đại học Y Dược thành phố Hồ Chí Minh.
4. Hoàng Minh Đỗ (2009), Nghiên cứu chẩn đoán và thái độ điều trị u não thể glioma ở bán cầu đại não, Luận án tiến sĩ Y học, Học viện Quân Y.
5. I. Shibahara, Y. Sonoda, T. Shoji, et al. (2015). Malignant clinical features of anaplastic gliomas without IDH mutation. Neuro-oncology, 17(1): 136-144.
6. B. K. Rasmussen, S. Hansen, R. J. Laursen, et al. (2017). Epidemiology of glioma: Clinical characteristics, symptoms, and predictors of glioma patients grade I–IV in the the Danish Neuro-Oncology Registry. Journal of Neuro-oncology, 135(3): 571-579.
7. R. Stupp, W. P. Mason, M. J. van den Bent, et al. (2005). Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma. The New England Journal of Medicine, 352(10): 987-996.
8. Y. Narita, S. Shibui (2015). Trends and outcomes in the treatment of gliomas based on data during 2001–2004 from the Brain Tumor Registry of Japan. Neurologia medico-chirurgica, 55(4): 286-95.
9. C. Hartmann, J. Meyer, J. Balss, et al. (2009). Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta neuropathologica, 118(4): 469-474.