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Date Published: 27/10/2023
Abstract Views: 459
Views PDF: 282
DOI: https://doi.org/10.51298/vmj.v531i1.6979
Issue
Vol. 531 No. 1 (2023)
Section
Các bài báo
How to Cite
Nguyễn , H. T. ., Nguyễn , M. T. ., Lê, T. D. T. ., Phùng , M. T. ., Nguyễn , P. D., Nguyễn , V. L. ., Trần, T. H. ., & Trần, T. T. T. . (2023). STUDY ON THE INFERTILITY MODEL IN HIGH-FAT DIET-INDUCED OBESE MALE MICE. Vietnam Medical Journal, 531(1). https://doi.org/10.51298/vmj.v531i1.6979

STUDY ON THE INFERTILITY MODEL IN HIGH-FAT DIET-INDUCED OBESE MALE MICE

Hoàng Tín Nguyễn 1,2, Minh Tiến Nguyễn 1, Thị Diễm Tiên Lê1, Minh Thư Phùng 1,2, Phúc Duy Nguyễn 1,2, Văn Luân Nguyễn 1,2, Thúy Huỳnh Trần3, Thái Thanh Tâm Trần1,2,
1 Can Tho University of Medicine - Pharmacy
2 Can Tho University of Medicine - Pharmacy hospital
3 Cantho Obstetrics & Gynecology Hospital,

Main Article Content

Abstract

Objectives: To evaluate the genital morphology and spermatogenesis process in obese male mice. Materials and method: Male mice (Swiss albino) were divided into two groups, (12 animals/group), the NFD group (Normal-fat diet) and the other for the HFD group (High-fat diet). Mice were examined for markers such as the weight of sex organs, semen analysis, serum testosterone levels, and seminal vesicle diameters after 6 weeks of obesity induction. Results: The testes and epididymis of mice in the HFD group were smaller than those in the NFD group (p<0.05). The HFD group's sperm concentration and the percentage of non-progressive and progressive sperms were lower than those of the NFD group (p<0.001). Additionally, the HFD group showed a higher proportion of immotile sperm and abnormal morphology of sperm than that of NFD group (p<0.001). The serum testosterone levels in the HFD group were 150% higher than those in the NFD group (p=0.001). The seminal vesicle diameters of mice in the HFD group was 8.35% smaller than that of mice in the NFD group (p<0.05). Conclusion: Obese mice displayed reproductive impairment after 6 weeks of modeling with a high-fat diet.

Article Details

Keywords

testosterone, spermatogenesis, semen analysis, sperm, obesity, Swiss albino

References

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