PHÂN TÍCH GEN IS1111 CỦA COXIELLA BURNETII Ở CÁC BỆNH NHÂN SỐT Q TẠI VIỆT NAM NĂM 2018-2019

Abstract

Objective: Decribe some epidemiological and clinical features of patients;  Phylogenetic analysis of C. burnetii sequences of the IS1111 gene was conducted to determine the genetic relatedness with previous isolates from the world. Materials and Methods: Descriptive cross-sectional study on Q fever patients at 27 hospitals in 26 provinces of Vietnam from 2018 to 2019. Main findings: 7 out of 29 patients included in the study (24,1%) yielded 7 sequences of the IS1111 gene. The mean age of the patients was 48,13 ± 10 (36-60). All Q fever patients (n=7) were male, rural inhabitants (100%), farmers (57,1%). The most common symptoms of Q fever were headache (100%), myalgia (86%), cough (63%), skin congestion (57%). In this study, none of the sample sequences clustered with previous isolates from the world. Conclusions: The prevalence of sequences of the IS1111 gene was 24,1% with a high proportion was men, people of working age, especially farmers, and who living in rural areas. None of Coxiella burnetii strain isolated in Vietnam have a common origin with strains isolated from different localities, on different samples such as cattle, buffaloes, cows, and ticks...