THE ADVERSE EVENTS OF GLUCOSAMINE USE IN OSTEOARTHRITIS TREATMENT
Main Article Content
Abstract
Background: Osteoarthritis is a worrying problem globally because of the increasing signs of aging in society. It affects the body's functions, can lead to disability and affects the patient's quality of life and creates an economic burden for both families and society. The purpose of this study was to focus on the identification of adverse events with glucosamine. Methodology: The review study was conducted based on searching for previous studies based on the Pubmed database. The studies were screened and selected according to the selection criteria. Results: There were 7 studies that met the criteria requirements. Studies showed that most patients using glucosamine report symptoms that are considered one of the symptoms of adverse events such as neurological, digestive and dermatological problems. Conclusion: The choice of using glucosamine depends not only on clinical effectiveness but also on the patient's ability to pay. Glucosamine is safe for all patients, and serious side effects have not been reported.
Article Details
Keywords
Glucosamine, Adverse Events, Osteoarthritis
References
2. An T. Glucosamine production from poultry for osteoarthritis. Accessed June 11, 2023. Vietnam ECONOMIC NEWS website: https://ven.vn/glucosamine-production-from-poultry-for-osteoarthritis-44246.html
3. Dat T. Thoái hóa xương khớp sớm nếu bạn thường xuyên có những thói quen này. Sở Y Tế Hà Nội. Accessed June 11, 2023. So Y Te Ha Noi Website: https://soyte.hanoi.gov.vn/kham-chua-benh-pho-bien-kien-thuc-y-hoc/-/asset_publisher/4IVkx5Jltnbg/content/thoai-hoa-xuong-khop-som-neu-ban-thuong-xuyen-co-nhung-thoi-quen-nay
4. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. Jan 27 2001;357 (9252):251-6. doi:10.1016/S0140-6736(00)03610-2
5. Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. Oct 14 2002;162(18):2113-23. doi:10.1001/archinte.162.18.2113
6. Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum. Feb 2007;56(2):555-67. doi: 10.1002/art.22371
7. Frestedt JL, Walsh M, Kuskowski MA, Zenk JL. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial. Nutr J. Feb 17 2008;7:9. doi:10.1186/1475-2891-7-9
8. Giordano N, Fioravanti A, Papakostas P, Montella A, Giorgi G, Nuti R. The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled trial. Curr Ther Res Clin Exp. Jun 2009;70(3):185-96. doi:10.1016/ j.curtheres.2009.05.004
9. Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. Jan 29 2016;15:14. doi:10.1186/s12937-016-0130-8
10. Hochberg MC, Martel-Pelletier J, Monfort J, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Journal Article; Clinical Trial Protocol. Annals of the rheumatic diseases. 2016;75(1):37‐44. doi:10.1136/ annrheumdis-2014-206792