MỘT SỐ ĐẶC ĐIỂM DỊCH TỄ, LÂM SÀNG VÀ CẬN LÂM SÀNG Ở THAI PHỤ MANG GEN BỆNH TAN MÁU BẨM SINH ĐẾN KHÁM TẠI BỆNH VIỆN PHỤ SẢN TRUNG ƯƠNG, 2012 – 2022

Abstract

Objective: Describe some epidemiological, clinical and paraclinical characteristics in pregnant women with congenital hemolytic disease gene examined at the National Obstetrics Hospital, 2012-2022. Subjects and methods: Cross-sectional descriptive study on medical records of 1292 pregnant women who came for prenatal check-ups at the National Obstetrics Hospital, 2012-2022. Analyze blood test indicators: RBC, HGB, HCT, MCH, MCV, MCHC, RDW, serum ferritin, serum iron, hemoglobin electrophoresis and explore the pregnant woman's thalassemia history. Results: The highest rate of carrying the thalassemia gene is among the Nung, Dao and San Diu ethnic groups. All pregnant women of the Nung, Dao and San Diu ethnic groups who were genetically tested carried the thalassemia gene. The age group from 25 to 29 years old accounts for the highest proportion with 28.72%. The severity of anemia in pregnant women is proportional to the number of mutated α genes and depends on the β-thalassemia genotype. Conclusion: There is a relationship between anemia in pregnant women and the number of mutated α genes and β-thalassemia genotype.