KẾT QUẢ HÓA XẠ TRỊ ĐỒNG THỜI TRIỆT CĂN UNG THƯ THỰC QUẢN GIAI ĐOẠN III-IVA BẰNG PHÁC ĐỒ CF TẠI BỆNH VIỆN UNG BƯỚU THANH HÓA

Abstract

Objective: Description of clinical and subclinical characteristics and assessment of treatment results, some toxicity of patients with stage III-IVA esophageal cancer undergoing chemoradiotherapy concurrently with CF regimen at Oncology hospital Thanh Hoa. Subjects and Methods: Retrospective study on 38 patients with stage III-IVA esophageal cancer who received chemoradiotherapy concurrently with CF regimen at Thanh Hoa Oncology Hospital from January 2015 to December 2020. Results: The average age was 56.5± 5.9, the male/ female ratio was 37/1, the main reason for admission was choking, accounting for 76.3%, the site of the lesion in the middle/lower was 22/16, there were 14 patients in stage III (36.8%), 24 patients in stage IVA (63.2%), 100% of patients were squamous cell carcinoma. The rate of complete response after concurrent exhaustively chemoradiotherapy was 34.2%, partial response rate was 55.3%, unchanged disease rate was 7.9%, progression rate was 2.6%. The overall survival rates at 12 months, 18 months, and 24 months were 81.6%, 57.9%, 31.6%, respectively. The 18 and 24 months survival rates with stage III were 71.4%, 42.9%, respectively, with stage IVA were 45.8%, 25%, respectively (p=0.032). Hematologic toxicity was leukopenia 26.3%, thrombocytopenia 5.3%. Radiation dermatitis was  68.4%, radiation- induced esophagitis was 42.1%. No cases of lung and cardiovascular damage have been recorded. Conclusion: The regimen gave good results and toxicity was within acceptable limits.