SURVEY ON THE CHANGES OF HEMATOLOGICAL PARAMETERS IN COVID-19 PATIENTS AT DONG NAI GENERAL HOSPITAL IN 2021

Mỹ Kim Lê1, Hà Hữu Phước Đặng 2, Thị Minh Thuận Nguyễn 1,
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 Dong Nai general hospital

Main Article Content

Abstract

Objective: To survey the changes in hematological parameters in COVID-19 patients. Methods: Data from 654 medical records of COVID-19 patients treated at Dong Nai General Hospital were collected in the retrospective study from August to December 2021. The changes in hematological parameters were analysed in patients with COVID-19 classified by disease severity using the guidelines of the Vietnam Ministry of Health. Results: The mean age of the study population was 56.7 ±16. The COVID-19 patients with critical illness had the highest rate (56.9%), twice that of the moderate patient group (26.4%), and three times higher than that of the severe group (16.7%). The percentage of patients with blood type O was the highest. White blood cell count and percentage neutrophil (%NEU) increased only in critically ill patients. The NEU of the critically ill patients was 2 times higher than that of the moderate patients and 1.5 times higher than that of the severe group. LYM and %LYM decreased in the severe patients and the most in the critically ill patients. Critical illness has the strongest influence on the change in these hematological parameters (p <0.001). However, monocyte count and percentage, red blood cell count, hemoglobin concentration, red blood cell distribution, and platelet count were within the reference threshold. Conclusion: the assessment of hematological changes in patients with COVID-19 can predict the risk of disease progression.

Article Details

References

1. Bộ Y tế. Quyết định số 250/QĐ-BYT. Quyết định về việc ban hành Hướng dẫn chẩn đoán và điều trị COVID-19. 2022: 1-66.
2. Al-Saadi E, Abdulnabi MA. Hematological changes associated with COVID-19 infection. J Clin Lab Anal. 2022;36(1):1-12
3. Bilgir F, Calik S, Demir I, Bilgir O. Roles of certain biochemical and hematological parameters in predicting mortality and ICU admission in COVID-19 patients. Rev Assoc Med Bras (1992). 2021;67 (Suppl 1):67-73.
4. Dubey DB, Mishra S, Reddy HD, Rizvi A, Ali W. Hematological and serum biochemistry parameters as a prognostic indicator of severally ill versus mild Covid-19 patients: A study from tertiary hospital in North India. Clin Epidemiol Glob Health. 2021;12:1-5
5. Hwaiz RA, Zaki Abdullah SM, Jalal Balaky ST, et al. Clinical and hematological characteristics of 300 COVID-19 patients in Erbil, Kurdistan Region, Iraq. Int J Immunopathol Pharmacol. 2022;36:1-9
6. Khalid A, Ali Jaffar M, Khan T, et al. Hematological and biochemical parameters as diagnostic and prognostic markers in SARS-COV-2 infected patients of Pakistan: a retrospective comparative analysis. Hematology. 2021;26(1):529-542.
7. Tahir Huyut M, Huyut Z, Ilkbahar F, Mertoglu C. What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality? Int Immunopharmacol. 2022;105:1-12
8. Waris A, Din M, Khalid A, et al. Evaluation of hematological parameters as an indicator of disease severity in Covid-19 patients: Pakistan's experience. J Clin Lab Anal. 2021;35(6):1-10