ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ UNG THƯ VÚ THỂ DỊ SẢN TẠI BỆNH VIỆN K

Abstract

Purpose: We evaluated the clinicopathological characteristics of metaplastic breast cancer (MBC), a rare entity of breast malignancy, along with disease-free survival and prognosis factors. Methods: A retrospective study was conducted on patients with stage I-III MBC at the Vietnam National Cancer Hospital from January 2017 to February 2023. Results: Of the 92 patients, 32 patients (34,8%) had clinical lymph node involvement and the median primary tumor size of 3,56 ± 0,21 cm.  62 patients (66,3%) were diagnosed with stage II, followed by 17 patients (18.5%) with stage III, and 14 patients (15,2%) with stage I. Only 15,2% and 27,2% cases had showed typical features of breast cancer on mammography and ultrasound, respectively. On immunohistology, the majority was triple negative breast cancer, accounting for 71,7%. The two- and three-year disease-free survival (DFS) rate was 77,7% and 73,8% respectively. Univariable analysis showed that tumor size, lymph node metastasis, stage at diagnosis, neoadjuvant and adjuvant chemotherapy were associated with survival of patients with MBC. However, only tumor size was an independent predictor of three-year DFS with a p-value of 0,028 on multivariable analysis. Conclusions: MBC demonstrated early disease progression and poor DFS with atypical presentation on routine imaging. Current standard treatments are ineffective, highlighting the urgent need for research to identify innovative therapeutic strategies for MBC patients.