CHARACTERISTICS OF FUNCTIONAL ETIOLOGIES AND ANTI-FUNGAL DRUG RESISTANCE IN COVID-19 PATIENTS WITH VENTILATOR-ASSOCIATED PNEUMONIA AT THE NATIONAL HOSPITAL OF TROPICAL DISEASES HOSPITAL (4/2021 - 3/2022)

Mạnh Hùng Thân1,2,, Quốc Phương Nguyễn2,3
1 VNU Hanoi-University of Medicine and Pharmacy
2 Central Tropical Diseases Hospital
3 HMU

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Abstract

Objectives: Research on fungal etiology and resistance to antifungal drugs of isolated fungal strains in COVID-19 patients with ventilator-associated pneumonia at the National Hospital for Tropical Diseases. Methods: We did a retrospective and prospective analysis of 151 COVID-19 patients with ventilator-associated pneumonia, between 04/2021 and 03/2022, at National Hospital of Tropical Diseases. Results and conclusions: C. albicans accounted for the highest proportion of 46.4%; followed by A. fumigatus and C. tropicalis, the proportions are 27.2% and 23.8%, respectively. C. albicans resistant to fluconazole accounted for 3.6% and resistant to amphotericin B accounted for 1.8%. C. tropicalis resistant to fluconazole accounted for 24.1%.

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References

Bộ Y tế. (2021). Hướng dẫn chẩn đoán và điều trị COVID-19 do chủng vi rút Corona mới (SARS-CoV-2).
2. Guan W jie, Ni Z yi, Hu Y, et al. 2020. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. doi:10.1056/ NEJMoa2002032
3. Goyal P, Choi JJ, Pinheiro LC, et al. 2020. Clinical Characteristics of Covid-19 in New York City. N Engl J Med. :NEJMc2010419. doi:10.1056/NEJMc2010419
4. Bộ Y tế. (2015). Hướng Dẫn Chẩn Đoán và Xử Trí Hồi Sức Tích Cực.
5. Meawed TE, Ahmed SM, Mowafy SMS, Samir GM, Anis RH. 2021. Bacterial and fungal ventilator associated pneumonia in critically ill COVID-19 patients during the second wave. J Infect Public Health.;14(10):1375-1380. doi:10.1016/ j.jiph.2021.08.003
6. Farag AM, Tawfick MM, Abozeed MY, Shaban EA, Abo-Shadi MA. 2020. Microbiological profile of ventilator-associated pneumonia among intensive care unit patients in tertiary Egyptian hospitals. J Infect Dev Ctries.; 14(2):153-161. doi:10.3855/jidc.12012
7. Thư N.K. (2022). Đánh giá kết quả điều trị người bệnh viêm phổi do nấm tại Bệnh viện Bệnh Nhiệt đới Trung ương. Tạp chí y học Việt Nam, 515.
8. Bộ Y tế. (2021). Hướng Dẫn Chẩn Đoán và Điều Trị Nhiễm Nấm Xâm Lấn.