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Date Published: 24/11/2023
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DOI: https://doi.org/10.51298/vmj.v532i1.7307
Issue
Vol. 532 No. 1 (2023)
Section
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How to Cite
Đỗ, A. T., Nguyễn, X. H., & Nguyễn, Đình L. (2023). TIME TO TREATMENT FAILURE IN METASTATIC PROSTATE CANCER TREATED WITH SEQUENTIAL ADT AND ADT PLUS ABIRATERONE ACETATE. Vietnam Medical Journal, 532(1). https://doi.org/10.51298/vmj.v532i1.7307

TIME TO TREATMENT FAILURE IN METASTATIC PROSTATE CANCER TREATED WITH SEQUENTIAL ADT AND ADT PLUS ABIRATERONE ACETATE

Anh Tú Đỗ1,, Xuân Hậu Nguyễn2, Đình Lợi Nguyễn2
1 K Hospital
2 HMU

Main Article Content

Abstract

Background: Our study evaluated time to treatment failure of patients with metastatic prostate cancer (mPCa) received sequential ADT and ADT plus Abiraterone acetate (AAP). Methods: This retrospective, observational study collected data from metastatic prostate cancer treated with sequential ADT and ADT plus Abiraterone acetate in Vietnam National Cancer Hospital. Kaplan-Meier curves were used to estimate time to treatment failure (TTF). The impact of baseline characteristics on TTF was explored using univariate and multivariate Cox proportional hazard models. Results: Data from 65 eligible patients were analyzed. The median age was 67 years (interquartile range [IQR]: 62–74). The rate of patients de novo was 75,4%, Gleason ≥ 8 was 78,5%, and ECOG PS ≥ 2 was 24,6%. The rate of patients with high burden was 46,2%. The median PSA was 150,6 ng/ml (IQR: 41,6-292,2). The median time to treatment failure was 34.0 months (95% CI: 24.9-43.0). ECOG PS ≥ 2, and time from ADT start to mCRPC (< 12 months) were predictive factors independent of TTF (p < 0.05). Conclusion: The median time to treatment failure was 34.0 months (95% CI: 24.9-43.0). ECOG PS ≥ 2, and time from ADT start to mCRPC (< 12 months) were predictive factors independent of TTF (p < 0.05

Article Details

Keywords

Metastatic prostate cancer (mPCa), ADT, ADT plus Abiraterone acetate, time to treatment failure.

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