Article Sidebar
Views pdf: 75
COMPARE THE EFFECTIVENESS OF GRANISETRONE AND ONDANSETRONE IN PREVENTING NAUSEA AND VOMITING IN WOMEN UNDERGOING SPINAL ANESTHESIA FOR CESAREAN SECTION
Main Article Content
Abstract
Objects: To compare the effectiveness of Granisetrone and Ondansetrone in preventing nausea and vomiting in women undergoing spinal anesthesia for cesarean section. Methods: RCT study on 100 patients divided into two groups. Group 1: Using Granisetrone 1mg injection before spinal anesthesia. Group 2: Using Ondansetrone 1mg injection before spinal anesthesia. Results: Both study groups had a statistically significant lower rate of nausea and vomiting, with the theoretical risk of nausea and vomiting corresponding to the Apfel scores. (p > 0.05). In the intraoperative period and early postoperative period, the rates of nausea and vomiting in the two study groups were similar (p > 0.05). In the late postoperative period (6–24 hours after surgery), the rate of nausea and vomiting in group 1 was statistically significantly lower than in group 2, with p < 0.05 (0% and 12%). Conclusion: Granisetrone has a long-lasting and superior efficacy in preventing post operative nausea vomiting (PONV) and it is superior to Ondansetrone in the late postoperative period in the first 24 hours after surgery in women undergoing spinal anesthesia for cesarean section.
Article Details
Keywords
: Granisetrone, Ondansetrone, spinal anesthesia for cesarean section
References
2. Mehta MV, Chudasama PA, Baria T. To Compare the Effectiveness of Granisetron Versus Ondansetron to Control Nausea and Vomiting During Lower Segment Cesarean Section Under Subarachnoid Block. Anesth Essays Res. 2022; 16(3): 378-380.
3. Balki M, Carvalho JC. Intraoperative nausea and vomiting during cesarean section under regional anesthesia. International journal of obstetric anesthesia. Jul 2005;14(3):230-241.
4. George RB, Allen TK, Habib AS. Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis. Anesth Analg. 2009;109(1):174-182.
5. Semiz A, Akpak YK, Yılanlıoğlu NC, Babacan A, Gönen G, Çam Gönen C, et al. Prediction of intraoperative nausea and vomiting in caesarean delivery under regional anaesthesia. J Int Med Res. 2017;45:332–9.
6. Patel. Comparison of injection granisetron versus injection ondansetron for control of intraoperative nausea and vomiting and post-operative nausea and vomiting among the women undergoing lower segment caesarean section under spinal anaesthesia.