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Date Published: 02/12/2023
Abstract Views: 84
Views PDF: 60
DOI: https://doi.org/10.51298/vmj.v532i2.7384
Issue
Vol. 532 No. 2 (2023): Vietnam Medical Journal
Section
Các bài báo
How to Cite
Tran, T. V. ., Lam, V. N. ., & Duong, H. K. L. . (2023). CORRELATION BETWEEN 1,5-ANHYDROGLUCITOL LEVELS AND GLYCEMIC VARIABILITY IN TYPE 2 DIABETIC PATIENTS USING CONTINUOUS GLUCOSE MONITORING . Vietnam Medical Journal, 532(2). https://doi.org/10.51298/vmj.v532i2.7384

CORRELATION BETWEEN 1,5-ANHYDROGLUCITOL LEVELS AND GLYCEMIC VARIABILITY IN TYPE 2 DIABETIC PATIENTS USING CONTINUOUS GLUCOSE MONITORING

Thanh Vinh Tran1,, Vinh Nien Lam2, Ha Khanh Linh Duong1
1 Biochemistry Department - Cho Ray Hospital
2 Biochemistry Department - University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Background: The evaluation and control of glycemic variability (GV) has been one of diabetes treatment targets recently. 1,5-anhydroglucitol (1,5-AG) is a test that can be used to evaluate GV. Objectives: 1. To survey the short-term change of 1,5-AG and HbA1c in patients with type 2 diabetes. 2. To assess the correlation between 1,5-AG and GV in patients with type 2 diabetes using continuous glucose monitoring system (CGM). Subjects and Methods: A descriptive cross-sectional study was conducted on 38 patients with type 2 diabetes using a CGM system for 7 days at Cho Ray Hospital. Spearman's rank correlation coefficient was used to determine the correlation between two variables. Non parametric tests were used to find the difference between groups at two time points. Results: The concentration of 1,5-AG after 7 days from the beginning of using the CGM system during inpatient treatment was 5.98 (5.39-7.01) μg/mL, greater than the initial time of 2.91 (2.41 - 4.32) μg/mL, p < 0.001. HbA1c levels after 7 days were similar to the measurements at the beginning of the study, 9.12 ± 1.92% and 9.23 ± 2.07%, respectively, p = 0.08. There was an inverse, moderate, and statistically significant relationship between the concentration of 1,5-AG and CoV of glycemia in 7 days, r was -0.45, p < 0.05. Conclusions: 1,5-AG can be utilized in evaluating glycemic variability and glycemic control in the short term.

Article Details

Keywords

Diabetes mellitus, 1,5-anhydroglucitol, HbA1c, glycemic variability

References

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