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Date Published: 02/12/2023
Abstract Views: 98
Views PDF: 81
DOI: https://doi.org/10.51298/vmj.v532i2.7394
Issue
Vol. 532 No. 2 (2023): Vietnam Medical Journal
Section
Các bài báo
How to Cite
Pham , V. M., Hoang , H. T., & Phan , T. H. (2023). THE ASSOCIATION BETWEEN SERUM VITAMIN D DEFICIENCY AND BONE MINERAL DENSITY IN CHRONIC KIDNEY DISEASE PATIENTS WITH REDUCED ESTIMATED GLOMERULAR FILTRATION RATE. Vietnam Medical Journal, 532(2). https://doi.org/10.51298/vmj.v532i2.7394

THE ASSOCIATION BETWEEN SERUM VITAMIN D DEFICIENCY AND BONE MINERAL DENSITY IN CHRONIC KIDNEY DISEASE PATIENTS WITH REDUCED ESTIMATED GLOMERULAR FILTRATION RATE

Van My Pham 1, Huy Truong Hoang 1,, Thanh Hang Phan 2
1 Pham Ngoc Thach University of Medicine
2 Trung Vuong Hospital

Main Article Content

Abstract

Background: Vitamin D deficiency is common in patients with chronic kidney disease (CKD), but its impact on bone health remains understudied. Methods: We collected data from CKD patients with eGFR < 60 mL/min/1.73m², including clinical information, 25-hydroxyvitamin D levels, and bone mineral density (BMD) measurements using DEXA between August 2020 and August 2021. Results: In a cohort of 96 patients, 63 (65.6%) were female, mean age was 62.3 ± 10.4 years, mean BMI was 22.8 ± 3.4 kg/m², and mean eGFR was 10.1 ± 7.3 ml/min. CKD staging included 13 (13.5%) in stage 3, 19 (19.8%) in stage 4, and 64 (66.7%) in stage 5, with or without dialysis. Mean serum vitamin D level was 21.3 ± 12.6 ng/ml. Hypovitaminosis D was prevalent in 74 (77.1%) cases, categorized as slight reduction in 19 (25.7%), moderate reduction in 33 (44.6%), and severe reduction in 22 (29.7%). Mean BMD at femoral neck was 0.725 ± 0.157 g/cm², and at lumbar spine, it was 0.873 ± 0.201 g/cm². Osteopenia and osteoporosis were found in 43 (44.8%) and 19 (19.8%) patients, respectively, at the femoral neck, and in 39 (40.6%) and 17 (17.7%) patients, respectively, at the lumbar spine. Statistically significant associations were observed between serum vitamin D levels and BMD at both sites: femoral neck (regression coefficient: 3.3 x 10-3, coefficient of determination: 0.09) and lumbar spine (regression coefficient: 5.1 x 10-3, coefficient of determination: 0.063). Conclusion: Vitamin D deficiency was common in CKD patients with eGFR < 60 ml/min/1.73m², and a modest but statistically significant association exists between serum vitamin D levels and BMD at both the femoral neck and lumbar spine

Article Details

Keywords

Vitamin D, bone mineral density, chronic kidney disease, reduced estimated glomerular filtration rate, eGFR

References

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