Article Sidebar
Views PDF: 47
CHARACTERISTICS OF OOCYTES AND EMBRYOS MATURED BY hCG COMBINED GnRHa
Main Article Content
Abstract
Objective: To evaluate the quantity and quality of oocytes, fertilization rates, and the quantity and quality of embryos of patients undergoing in vitro fertilization (IVF)-induced oocyte maturation with hCG combined with GnRHa. Subjects and methods: A retrospective description of 130 patients undergoing ovarian stimulation with in vitro fertilization using the GnRH antagonist regimen, inducing oocyte maturation by hCG combined with GnRHa, including 76 young patients (<35 years old) in Group I and 54 older patients (³35 years old) in Group II. Results: The overall average number of oocytes obtained was 12.25 ± 6.48, and the average number of mature oocytes accounted for 79.85 ± 17.4%. The average fertilization rate was 84.93 ± 15.51%, the average number of day 2 embryos obtained was 7.94 ± 4.49, and the potential embryo rate was 80.93 ± 9.25. The average number of oocytes obtained, the number of mature oocytes, and the number of embryos obtained in the younger group were higher than those in the older group with a 95% confidence level. However, there were no statistically significant differences in fertilization and useful embryo rates between the younger and older groups. Conclusion: Oocyte maturation with hCG combined with GnRHa yielded good results in terms of number of oocytes, oocyte maturity rate, fertilization rate, and rate of potential embryos.
Article Details
Keywords
In vitro fertilization, oocyte maturation, hCG combined with GnRHa, dual trigger
References
2. Shapiro, B. S., S. T. Daneshmand, F. C. Garner, M. Aguirre and C. Hudson (2011). "Comparison of “triggers” using leuprolide acetate alone or in combination with low-dose human chorionic gonadotropin." Fertility and sterility 95(8): 2715-2717.
3. Lin, M.-H., F. S.-Y. Wu, R. K.-K. Lee, S.-H. Li, S.-Y. Lin and Y.-M. Hwu (2013). "Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in GnRH-antagonist cycles." Fertility and sterility 100(5): 1296-1302.
4. Schachter, M., S. Friedler, R. Ron-El, A. L. Zimmerman, D. Strassburger, O. Bern and A. Raziel (2008). "Can pregnancy rate be improved in gonadotropin-releasing hormone (GnRH) antagonist cycles by administering GnRH agonist before oocyte retrieval? A prospective, randomized study." Fertility and sterility 90(4): 1087-1093.
5. Mutlu, I., E. Demirdag, F. Cevher, A. Erdem and M. Erdem (2022). "Dual trigger with the combination of gonadotropin-releasing hormone agonist and standard dose of human chorionic gonadotropin improves in vitro fertilisation outcomes in poor ovarian responders." Journal of Obstetrics and Gynaecology 42(5): 1239-1244.
6. Tùng, N. T. (2023). "So sánh hiệu quả phác đồ trưởng thành noãn kép và trưởng thành noãn bằng hCG đơn thuần trên nhóm đáp ứng buồng trứng bình thường ở các chu kỳ thụ tinh trong ống nghiệm." Tạp chí Y học Việt Nam 526(1B).
7. Dong, L., F. Lian, H. Wu, S. Xiang, Y. Li, C. Wei, X. Yu and X. Xin (2022). "Reproductive outcomes of dual trigger with combination GnRH agonist and hCG versus trigger with hCG alone in women undergoing IVF/ICSI cycles: a retrospective cohort study with propensity score matching." BMC Pregnancy and Childbirth 22(1): 583.
8. Haas, J., R. Bassil, N. Samara, E. Zilberberg, C. Mehta, R. Orvieto and R. Casper (2020). "GnRH agonist and hCG (dual trigger) versus hCG trigger for final follicular maturation: a double-blinded, randomized controlled study." Human Reproduction 35(7): 1648-1654.
9. Begueria, R., D. Garcia, A. Obradors, F. Poisot, R. Vassena and V. Vernaeve (2014). "Paternal age and assisted reproductive outcomes in ICSI donor oocytes: is there an effect of older fathers?" Human Reproduction 29(10): 2114-2122.