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Date Published: 11/12/2023
Abstract Views: 99
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DOI: https://doi.org/10.51298/vmj.v532i1B.7475
Issue
Vol. 532 No. 1B (2023)
Section
Các bài báo
How to Cite
Nguyễn , T. K. D. ., Đỗ , G. T. ., & NGuyễn , T. C. . (2023). EFFECTS OF MAINTENANCE DOSES OF MYCOPHENOLATE ON INFECTION COMPLICATION RATES IN KIDNEY TRANSPLANT RECIPIENTS. Vietnam Medical Journal, 532(1B). https://doi.org/10.51298/vmj.v532i1B.7475 (Original work published December 7, 2023)

EFFECTS OF MAINTENANCE DOSES OF MYCOPHENOLATE ON INFECTION COMPLICATION RATES IN KIDNEY TRANSPLANT RECIPIENTS

Thị Kim Dung Nguyễn 1, Gia Tuyển Đỗ 1, Thế Cường NGuyễn 2,
1 HMU
2 Viet Duc hospital

Main Article Content

Abstract

Objectives: To examine the usual maintenance dose of mycophenolate mofetil (MMF) in kidney transplant recipients treated in renal clinic of Vietduc University Hospital within the first 3 years after transplantation and to investigate the relationship between the maintenance dose of MMF with infectious complications in kidney transplant recipients. Methods: A retrospective, descriptive study included 200 kidney transplant recipients using a triple drug immunosuppressive regimen including Prednisolone, Tacrolimus (Prograf®), and MMF. Data was collected at 6 months, 12 months, 24 months, and 36 months after transplantation including immunosuppressive drugs doses, infection episodes and graft function. Results: After kidney transplantation, the dose of MMF tends to decrease gradually over time. MMF doses ≥ 31.83 mg/kg/day in the first 6 months have the potential to cause infection with a sensitivity of 57.5% and a specificity of 68.2%. Conclusion: MMF dose in the first 6 months is associated with infectious complications.

Article Details

Keywords

Mycophenolate, infection, kidney transplant.

References

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