NGHIÊN CỨU TỔNG QUAN HIỆU QUẢ ĐIỀU TRỊ BỔ TRỢ BẰNG CIDOFOVIR TRONG U NHÚ ĐƯỜNG HÔ HẤP TÁI PHÁT

Abstract

Objectives: Describe the characteristics of the research on the efficacy of cidofovir in the adjuvant treatment of recurrent respiratory papillomatosis, Treatment Outcome and Drug-Related Side Effects and Adverse. Subjects and methods: Articles, studies textbooks in 2 databases PubMed, Cochrane met the research criteria. Result: Found 90 documents. After analysis, 21 articles were included in the study: the treatment effect of cidofovir 19/21 documents mentioned in which 94.74% of the studies concluded that cidofovir is effective in adjuvant treatment of RPP. There are 52.5% patients in complete remission, 34.25% of patients in partial remission. 9 out of 19 studies found a reduction in the number of surgeries performed per year. Side effects of the drug are mentioned in 3(20%) documents, but they are described as mild and self-limiting, in 12(80%) of the studies, no side effects occurred. Regarding the pathological results, there were 7 (58.33%) studies reporting no dysplasia or carcinoma, 3 (25%) descriptive studies showing signs of dysplasia, 2(16, 67%) observed squamous cell carcinoma.