NGHIÊN CỨU ĐẶC DIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA BỆNH NHÂN NGHI NGỜ UNG THƯ ĐƯỜNG MẬT ĐƯỢC SINH THIẾT TRONG LÒNG ĐƯỜNG MẬT QUA DA TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI

Abstract

Purpose: To describe clinical and paraclinical features of patients with suspected malignant biliary strictures, who underwent biliary percutaneous transluminal forceps biopsy. Materials and methods: A retrospective and prospective, descriptive study of 52 patients with suspected malignant biliary strictures, who underwent biliary percutaneous transluminal forceps biopsy, at Ha Noi Medical University Hospital from Feb-2020 to Dec-2022. Results: Mean age was 64.8±10 years. Common clinical symptoms included abdominal pain, fever and jaudice with rates 92,3%, 57,7% and 55,8% respectively. The proportion of increased levels of total bilirubin, direct bilirubin and CA19-9 were more than 50%. The high level of biliirubin, CEA, CA 19-9 between malignant and benign biliary stenosis is no statistically significant difference (p>0.05). The common sites of bile duct strictures included the hilum, the lower segment of the common bile duct, and the intrahepatic bile duct with rates 36,5%, 32,7% and 30,8% respectively. The presence of irregular margin, asymmetry, restricted diffusion and increasing enhancement of strictured bile duct were significant findings for malignancy (p < 0.001). The characteristic of sudden stenosis between malignant and benign biliary stenosis is no statistically significant difference (p>0.05). Conclusion: Biliary atresia suspected of cancer is common in middle-aged or elderly patients. Common clinical symptoms are abdominal pain, fever, and jaundice. Imaging features are highly valuable in differentiating malignant and benign biliary strictures, helping to diagnose cholangiocarcinoma early.