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Date Published: 07/12/2023
Abstract Views: 256
Views PDF: 87
DOI: https://doi.org/10.51298/vmj.v532i1B.7548
Issue
Vol. 532 No. 1B (2023)
Section
Các bài báo
How to Cite
Tống, T. H., Lê, Q. T., & Trần, T. K. M. (2023). SPLENECTOMY EVALUATION IN PATIENT IMMUNE THROMBPCYTOPENIA WHO DO NOT RESPONSE TO FIRST LINE THERAPY. Vietnam Medical Journal, 532(1B). https://doi.org/10.51298/vmj.v532i1B.7548

SPLENECTOMY EVALUATION IN PATIENT IMMUNE THROMBPCYTOPENIA WHO DO NOT RESPONSE TO FIRST LINE THERAPY

Thị Hương Tống1,, Quang Tường Lê1, Thị Kiều My Trần2
1 National Institute of Hematology and Blood Transfusion
2 HMU

Main Article Content

Abstract

Objectives: Study was done to evaluate on treatment results of patients immune thrombocytopenia (ITP) who do not respond to first line therapy. Subjects and methods: A descriptive prospective study of 20 patients with ITP who do not response to first line therapy. Results and conclusion: The mean age of the study group was 41.2 ± 16.2 years, rate of female/male is 1,22/1. Platelet count at first hospital admission was 8.3 ± 6.4G/l, the preoperative platelet count was 18.9 ± 17.9 with the time of therapy before splenectomy was 7.3 months. The response rate of splenectomy was 75%. The level of latelet count increased gradually after 1 week, 1 month and time to stop treatment. Response to splenectomy was found to be higher in patients who had the platelet count was more than 300 G/l on day 14 of surgery. The patients with no response and relapsed after splenectomy who required therapy corticoid combined eltrombopag, were more effective than prior to splenectomy, only 1 patient multirefractory. Four patients had mild infections and no patient died.

Article Details

Keywords

: Immune thrombocytopenia, splenectomy.

References

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