ĐÁNH GIÁ CÁC TÁC DỤNG KHÔNG MONG MUỐN CỦA CÁC CHẾ PHẨM VỆ SINH TAY DIỆT KHUẨN ĐIỀU CHẾ THEO CÔNG THỨC I (WHO) VÀ CÔNG THỨC I CẢI TIẾN

Abstract

The study was conducted to evaluate the unwanted effects of liquid and gel antibacterial handrubs prepared in accordance with Formula I (recommended by the World Health Organization) and another formula improved from Formula I (improved Formula I). Each antibacterial handrub was tested on volunteers for one week, then interviews were conducted to evaluate unwanted effects when using the product according to the guidance of the Ministry of Health such as itching, burning, flushing, dry skin, lumpy skin, greasy skin, and sticky feeling. The results showed that both liquid and gel handrubs prepared according to Formula I could cause some unwanted effects such as dry skin, cellulite, greasy skin, and a sticky feeling with medium and mild manifestations and with rates from 4.8% to 52.4%. However, liquid and gel handrubs prepared according to improved Formula I had few unwanted effects and only occurred with mild manifestations and with rates from 4.8% to 9.5%. Therefore, the liquid and gel handrubs prepared according to the improved Formula I helped to reduce undesired effects when using the antibacterial handrubs and these handrubs can be widely used for daily hand hygiene.