Article Sidebar

PDF
Date Published: 04/08/2021
Abstract Views: 1110
Views PDF: 209
DOI: https://doi.org/10.51298/vmj.v503i2.763
Issue
Vol. 503 No. 2 (2021)
Section
Các bài báo
How to Cite
Trường Sinh, C. ., & Ngọc Linh, H. . (2021). TO EVALUATE THE EFFECT OF LISINOPRIL AND AMLODIPIN COMBINATION PILL IN THE TREATMENT OF HYPERTENSION BY METER THE PULSE WAVE VELOCITY VP PLUS 1000. Vietnam Medical Journal, 503(2). https://doi.org/10.51298/vmj.v503i2.763

TO EVALUATE THE EFFECT OF LISINOPRIL AND AMLODIPIN COMBINATION PILL IN THE TREATMENT OF HYPERTENSION BY METER THE PULSE WAVE VELOCITY VP PLUS 1000

Cao Trường Sinh, Hoàng Ngọc Linh

Main Article Content

Abstract

Aim: To evaluate the antihypertensive effect of lisinopril and amlodipine combination pill by the meter of pulse wave velocity. Objects and methods: 40 patients with primary hypertension, mean age 69.18 ± 10.4. All patients were measured blood pressure, pulse wave velocity (baWPV), ankle brachial index by the meter of pulse wave velocity VP Plus 1000 before entering treatment. All patients were then given the Lisonorm combination pill (lisinopril 10 mg and amlodipine 5 mg) for 4 weeks. After 4 weeks, the  patients was measured again with the same machine, the pulse wave velocity of VP Plus 1000. Results: After 4 weeks, right arm blood pressure decreased: 26.58 ± 9.51 mmHg/ 8.6 ± 4.47 mmHg; Left arm blood pressure decreased: 26.88 ± 11.27/13.55 ± 8.15mmHg; Right ankle blood pressure decreased: 23.75 ± 11.78/10.75 ± 6.64mmHg; Left ankle blood pressure decreased: 30.33 ± 16.64/13.6 ± 9.28mmHg; The rate of patients with the target blood pressure was 72.5% (29/40 patients). Right baPWV decreased 593,65 ± 416,59 cm/s; Left baPWV decreased 585,4 ± 447,19 cm/s.  Conclusion: The combination tablet of lisinopril 10mg and amlodipine 5mg effectively lowers blood pressure in both extremities and pulse wave velocity, and reduces vessel wall stiffness when measured by meter the pulse wave velocity VP Plus 1000.

Article Details

Keywords

lisinopril and amlodipine combination pill, the meter of pulse wave velocity

References

1. Forouzanfar M.H. et al.(2017), “Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mmHg, 1990-2015”, The Journal of the American Medical Association, 317(2): 165-182.
2. Huỳnh Văn Minh, Nguyễn Lân Việt (2020), “Asian management of hypertension: Current status, home blood pressure, and specific concerns in Viet Nam, Journal Clinical Hypertension 2020:22:519-521.
3. Phạm Chí Hiền; Nguyễn Thiện Tuấn; Sử Cẩm Thu (2015),” Đánh giá hiệu quả và an toàn của thuốc LISONORM phối hợp cố định chứa 10 mg LISINOPRIL và 5mg AMLODIPIN trên bệnh nhân THA tại An Giang”, Báo cáo khoa học Bệnh viện Đa khoa An Giang 2015, tr.44-53.
4. Vinay.K.Balt, et al.(2012), “Management of hypertension with the fixed combination of perindopril and amlodipine in daily clinical practice”, American Journal of Cardiovascular Drugs 9, 135-142.
5. Mur Naidu, PR Usha, TRamesh Kumar Rao, JC Shobha (2000), “Evaluation of amlodipine, lisinopril, and a combination in the treatment of essential hypertension”, Postgrad Med J., 76(896): 350–353.
6. Semagina, I.; Kotovskaya, Y.; Kobalava. (2015), ”Effects of Lisinopril/ amlodipine single pill combination on ambulatory brachial and central blood pressure in hypertensive subjects with non- alcoholic fatty liver diese”, Journal of Hypertension, Vol33:p199.
7. Tetsuya Ichihara, et al.(2005), ”Selective angiotensin receptor antagonism with valsartan decreases arterial stiffness independently of blooad pressure lowering in hypertensive patients”, Hyperten Res. 28 (12):937-43.
8. Cao Trường Sinh (2015), ”Nghiên cứu chỉ số cổ chân-cánh tay ở bệnh nhân tăng huyết áp nguyên phát”, Tạp chí Y học thực hành, số 971 (7/2015), tr 54-57.
9. Deirdre A Lane, Gregory YH Lip, (2013), ”Treatment of hypertension in peripheral arterial disease”, Cochrane Database Syst Rev, 7:3075.