CORRELATION BETWEEN MOTOR COMPLICATIONS AND DELAYED GASTRIC EMPTYING IN PARKINSON’S DISEASE

Trần Thanh Hùng, Vũ Anh Nhị, Nguyễn Xuân Cảnh

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Abstract

Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer disease. Delayed gastric emptying could be an important pharmacokinetics mechanism causing motor complications in PD patients. Objectives: To investigate the correlation between PD and delayed gastric emptying. Methods: A cross-sectional study was conducted on PD patients with their informed consent. Patients were evaluated on their motor complications and were also received radionuclide gastric emptying study using solid meal. The analysis was done using R version 4.0.3. Results: Seventy-two patients were included in our study with 73.6% were female. There were 72.2% patients with at least one motor complications. The delayed gastric emptying rate was 45.8%. Patients with delayed ON had higher percentage of delayed gastric emptying (66.67%) compared to patients without delayed ON (38.89%) with statistically significant using χ2 (p = 0.041). Conclusions: Delayed ON motor complications needs to be recognized to evaluate delayed gastric emptying and efficacy of oral medication in PD patients.

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References

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