THE CHARACTERISTICS OF THE AXILLARY LYMPH NODE METASTASIS IN INVASIVE LOBULAR BREAST CARCINOMA

Thúy Hòa Ngô 1,, Thị Uyên Lê1, Hồng Hải Đăng Tạ 1,2
1 k hospital
2 HMU

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Abstract

This report aims to assess the rate of lymph node metastasis and the correlation between lymph node metastasis and some risk factors in invasive lobular breast carcinoma. A descriptive cross-sectional study was conducted on 98 patients with invasive lobular breast carcinoma at the Department of Pathology - Cytology, National Cancer Hospital from January 2019 to April 2023. The study results show that the rate of lymph node metastasis was 48,0%. The factors associated with the increased risk of lymph node metastasis were large tumor size, high tumor grade, the presence of lymphovascular invasion, ER expression, some molecular subtypes (triple-negative breast cancer, luminal B-like breast cancer, and HER2-enriched breast cancer) (p < 0,05). The results of this study hope to aid patient selection for axillary lymph node dissection and improve patient counseling.

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References

1. Ashturkar AV, Pathak GS, Deshmukh SD, Pandave HT. Factors Predicting the Axillary Lymph Node Metastasis in Breast Cancer: Is Axillary Node Clearance Indicated in Every Breast Cancer Patient? Indian Journal of Surgery. 2011; 73(5):331-335, doi: 10.1007/s12262-011-0315-5
2. Yılmaz, Trabzonlu, Güler et al. Characteristics of Special Type Breast Tumors in Our Center. European Journal of Breast Health. 2018;14(1):17-22
3. Fernández B, Paish EC, Green AR, et al. Lymph-node metastases in invasive lobular carcinoma are different from those in ductal carcinoma of the breast. J Clin Pathol. 2011;64(11): 995-1000. doi: 10.1136/ jclinpath-2011-200151
4. Viale G, Zurrida S et al, Predicting the status of axillary sentinel lymph nodes in 4351 patients with invasive breast carcinoma treated in a single institution. Cancer. 2005;103(3):492-500. doi:10.1002/cncr.20809
5. Tan LGL, Tan YY, Heng D, Chan MY. Predictors of axillary lymph node metastases in women with early breast cancer in Singapore. Singapore Med J. 2005;46(12):693. doi:10.1016/s0959-8049(98)80134-2
6. Barth A, Craig PH, Silverstein MJ. Predictors of axillary lymph node metastases in patients with T1 breast carcinoma. Cancer. 1997;79(10):1918-1922. https://doi.org/10.1002/(SICI)1097-0142 (19970515)79:10<1918::AID-CNCR12>3.0. CO;2-Y
7. Makki J. Diversity of Breast Carcinoma: Histological Subtypes and Clinical Relevance. Clinical Medicine Insights: Pathology. 2015;8:23-31. doi:10.4137/cpath.s31563