NGUY CƠ TIM MẠCH THEO THANG ĐIỂM FRAMINGHAM TRÊN BỆNH NHÂN VẢY NẾN MẢNG: MỘT NGHIÊN CỨU BỆNH CHỨNG TẠI BỆNH VIỆN DA LIỄU THÀNH PHỐ HỒ CHÍ MINH

Abstract

Objectives: Assessment of cardiovascular risk in psoriasis patients using the Framingham Risk Score (FRS). Subjects and methods: A paired case-control study involving 40 psoriasis patients and 40 non-psoriasis controls. Plaque psoriasis was confirmed by clinical symptoms and the severity was evaluated using the PASI score. Factors related to cardiovascular risk were assessed using a questionnaire. We calculated cardiovascular risk based on Framingham Risk Score (FRS) by using Medscape (https://reference.medscape.com/calculator/252/framingham-risk-score-2008). We used SPSS software to perform data analysis. Results: Psoriasis patients had a significant increase in high cardiovascular risk based on Framingham risk Score (FRS) compared to the controls (25% versus 7,5%, p = 0,042). There were some factors related to psoriasis, including smoking status (p = 0,021), overweight (p = 0,043), central obesity (p < 0,001), and low HDL-c level (p = 0,028). Alcohol consumption showed no significant difference (p = 0,39). Moderate-to-high cardiovascular risk in psoriasis patients was associated with metabolic syndrome (p = 0,028; OR = 4,40; 95% CI: 1,13 - 17,07) and low cardiovascular risk in psoriasis patients was associated with early onset (before the age of 40) (p = 0,012; OR = 5,49; 95% CI: 1,39 - 21,59). Conclusion: Our results indicated some important cardiovascular risks in psoriasis patients, as well as a higher Framingham risk score compared to the controls. Psoriasis patients with metabolic syndrome and early onset are associated with cardiovascular risk. These pieces of evidence will support an effective strategy of screening for comorbidities in psoriasis patients.