ĐÁNH GIÁ SỰ BIẾN ĐỔI TẾ BÀO NỘI MÔ SAU PHẪU THUẬT PHACO VỚI ĐƯỜNG RẠCH 2,2 MM GIỮA BỆNH NHÂN CÓ VÀ KHÔNG CÓ ĐÁI THÁO ĐƯỜNG TÝP 2

Abstract

Purpose: To evaluate the corneal endothelial cell density and morphology between non-diabetic and type 2 diabetic patients after phacoemulsification with intraocular lens implantation. Method: A clinical prospective study including 41 patients with type II diabetes and 41 control patients without diabetes scheduled to undergo cataract surgery. The visual acuity, intraocular pressure, endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells (HEX), and central corneal thickness (CCT) were recorded at preoperative, at 1 week, at 1 month, and at 3 months postoperatively. Results: The mean decrease in endothelial cell density at 3 months in the diabetic group was 28,95% ± 15,21% compared with 10,17% ± 7,52% in the control group (P=0,0000). A significant decrease in HEX was also seen in the diabetic group (P= 0,032). A difference in CCT between 2 groups was also significant (P=0,004). There was no statistically significant change in CV and intraocular pressure between two groups (P = 0,364 and P = 0,895). Visual acuity increased significantly and equally in the 2 groups (P = 0,832). No relation between diabetic duration and corneal endothelial cell changes after the surgery. Conclusions: The present study shows a great loss of corneal endothelial cell density in a diabetic group under good glycemic control compared with the control group at 3 months postoperatively. The morphological changes in the endothelial cells revealed an impaired function as judged by CCT. The impact of diabetes on the morphology and function of corneal endothelial cell was not related to the diabetic duration.