KHÁNG KHÁNG SINH TIÊN PHÁT CỦA HELICOBACTER PYLORI Ở TRẺ EM LOÉT DẠ DÀY TÁ TRÀNG TẠI BỆNH VIỆN NHI TRUNG ƯƠNG NĂM 2023

Abstract

A cross-sectional study was conducted among 59 children with peptic ulcer aged from 6 to 17 years old at the Gastrointestinal Clinic, National Children’s Hospital from August 2022 to July 2023.  We conducted this study to determine the severity of resistance to H. pylori primary antibiotic resistance in children with peptic ulcer. We assessed H. pylori antibiotic resistance with clarithromycin, levofloxacin, amoxicillin, tetracycline and metronidazole by Etest. We observed 59 strains (100%) of H. pylori resistant to antibiotics, 1 strain resistant to monoresistant antibiotic; 58 strains resistant to multi drug resistant (MDR). we observed that resistance to clarithromycin was the most predominant with the highest proportion of 100%. Resistance to amoxicillin, levofloxacin and metronidazole, were 98.3%, 10.2% and 3.4 %, respectively. No strains of H. pylori resistant to tetracycline. Co-resistance to 2 antibiotics was observed among 98.3% for clarithromycin and amoxicillin, and 3.4% for amoxicillin and metronidazole. Triple resistance to amoxicillin, clarithromycin, and Levofloxacin was 10.2%. Since primary antibiotic resistance of H. pylori among children with peptic ulcer is common, it is necessary to the use antimicrobial susceptibility test before prescribing antibiotics in order to improve the effectiveness of H. pylori eradication.