NGHIÊN CỨU TÌNH TRẠNG BỘC LỘ PROTEIN MMR Ở BỆNH NHÂN UNG THƯ BIỂU MÔ ĐẠI TRỰC TRÀNG TẠI BỆNH VIỆN BẠCH MAI

Abstract

Background: Microsatellite instability (MSI) is one of three pathways leading to colorectal cancer due to DNA mismatch repair (MMR) deficiency. Patients with dMMR have a different prognosis and treatment than patients with pMMR. Objective: Evaluate the dMMR rate and correlate with histopathology in patients with colorectal carcinoma at Bach Mai Hospital. Methods: 105 patients with colorectal carcinoma were studied by immunohistochemitry and histopathology. Results: The dMMR rate is 12.4%. The most frequent expression pattern was combined loss of MLH, and PMS2 (53,8 %dMMR) followed by a combined loss of MSH2, and MSH6 (30,8% dMMR). In the dMMR group, the proportions of tumors with a size of ≥5cm, mucinous type, and poor differentiation grade were higher than in the pMMR group. Tumors with dMMR were usually stage II or III. Conclusion: dMMR status and tumor size were statistically significantly related (p=0.048). Characteristics such as histologic type, histologic grade and disease stage did not have a statistically significant associations with dMMR status (p>0.05).