ĐẶC ĐIỂM LÂM SÀNG VÀ DỊCH TỄ VIÊM GIÁC MẠC DO MICROSPORIDIA

Abstract

Purpose: To review the clinical finding of patients with Microsporidial stromal keratitis who underwent penetrating keratoplasty to determine which factors at presenting visit that can predict the risk factors and the needs of surgery. Methods: A retrospective descriptive study of all cases, who was diagnosed and underwent therapeutic corneal transplantation between January 2018 and December 2020 at Viet Nam Eye Hospital. Data collected including demographics, clinical finding, management was analyzed. Potential predictors for TPK was obstained and determine which factors at presenting. Results: 63 eyes of 62 patients was analysed. Bilateral involvement was seen in 1 patient (1.6%). 74.6% of patients were female. The mean age was 60.8±10.1 years (range 34-86). The mean duration of symptoms was 10.1± 9.7 months (range 1.3-50.2 months). Risk factors include using long-term topical steroid, a history of ocular trauma. Visual acuity was ≤ CF 3m in 92.0%. Keratic precipitates were present in 47.6%, hypopyon were present in 66.7%. The reason for performing TPK includes medically unresponsive ulcer in 43 eyes (68.3%), perforated ulcer and perpending perforation in 6 eyes (9.6%). Conclusions: The most common risk factors: ocular trauma, prolonged steroid eyedrops. The diagnosis of Microsporidial stromal keratitis can be challenging and usually presents with non-specific corneal infiltration refractory to antimicrobial therapy. Therefore, we should consider Microsporidia in the differential diagnosis of infectious keratitis.