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Date Published: 11/01/2024
Abstract Views: 84
Views PDF: 76
DOI: https://doi.org/10.51298/vmj.v533i2.7955
Issue
Vol. 533 No. 2 (2023)
Section
Các bài báo
How to Cite
Lê, H. L. H. ., Lê, V. H. ., Nguyễn , T. H. V. ., Vũ , H. L. ., Lê, N. A. ., Nguyễn , T. T. M., Vũ , T. T. T. ., Vũ , T. H. ., Trần , T. N., Tạ , T. Đạt ., & Nguyễn, H. V. . (2024). MICA-129 Val/Met VARIANT ASSOCIATED WITH EPSTEIN-BARR VIRUS COPIES NUMBER IN NASOPHARYNGEAL CARCINOMA. Vietnam Medical Journal, 533(2). https://doi.org/10.51298/vmj.v533i2.7955

MICA-129 Val/Met VARIANT ASSOCIATED WITH EPSTEIN-BARR VIRUS COPIES NUMBER IN NASOPHARYNGEAL CARCINOMA

Hạ Long Hải Lê, Văn Hưng Lê, Thị Hà Vinh Nguyễn , Huy Lượng Vũ , Ngọc Anh Lê, Thị Thúy Mậu Nguyễn , Thị Thu Trang Vũ , Thị Hà Vũ , Tín Nghĩa Trần , Thành Đạt Tạ , Hoàng Việt Nguyễn

Main Article Content

Abstract

MICA protein (major histocompatibility complex (MHC) class I chain-related A) expressed on cancer and infection cells’s surface, play important role in cancer immune-surveillance via NKG2D receptor activated on NK cells and cytotoxic T cells. Interestingly, a methionine (Met) to valine (Val) substitution at position 129 of the heavy chain domain classified the MICA alleles into strong (MICA-129 Met) and weak (MICA-129Val) binders to NKG2D receptor, previous findings suggested to immune disorders associated with MICA variant. We analyzed on 164 nasopharyngeal carcinoma (NPC) tissues and found Val/Val (33.54%), Val/Met (46.34%) and Met/Met (20.12%), respectively. Allele frequency for Met was 43.29% and for Val was 56.741%. Notably, allele Val strongly related to Epstein-Barr virus (EBV) status in NPC tissues (p=0.04). Our results suggested that the usage of MICA-129 genotype as prognostic marker for immune therapy in the future.

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References

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